DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	288	Identity:	84/288 - (29%)
Similarity:	127/288 - (44%)	Gaps:	81/288 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCL-TDAIAAKIYTGATVF 138
            :||.||.:::.|.:|:|..|  |:.|..:  |||:||..::|:|||||. .|::|:.:..  |||
Human   566 SRIVGGAVSSEGEWPWQASL--QVRGRHI--CGGALIADRWVITAAHCFQEDSMASTVLW--TVF 624

  Fly   139 -----------ADVEDSVEELQVTHRDFIIYP-------DYLGFGGYSDLALIRLPRKVRTSEQV 185
                       .:|...|..|       :::|       ||       |:||::|...|..|..|
Human   625 LGKVWQNSRWPGEVSFKVSRL-------LLHPYHEEDSHDY-------DVALLQLDHPVVRSAAV 675

  Fly   186 QPIELAGEFMHQNFLVGKVVTLSGWGYLGDSTDKR---------------------TRLLQYLDA 229
            :|:.|...  ...|..|....::|||.|.:...:.                     :..||.:|.
Human   676 RPVCLPAR--SHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDV 738

  Fly   230 EVIDQERCICYFLPGLVSQRRHLCTDGSNG-RGACNGDSGGPVVY-----HWRNVSYLIGVTSFG 288
            ::|.|:.|...:...:..  |.||.....| :.||.||||||:|.     .|    :|.|:.|:|
Human   739 QLIPQDLCSEVYRYQVTP--RMLCAGYRKGKKDACQGDSGGPLVCKALSGRW----FLAGLVSWG 797

  Fly   289 SAEGCEVGGPT---VYTRITAYLPWIRQ 313
            .  ||  |.|.   ||||||..:.||:|
Human   798 L--GC--GRPNYFGVYTRITGVISWIQQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	81/283 (29%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	83/286 (29%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	83/286 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910