DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT16 and LamC

DIOPT Version :9

Sequence 1:NP_005548.2 Gene:KRT16 / 3868 HGNCID:6423 Length:473 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:401 Identity:123/401 - (30%)
Similarity:181/401 - (45%) Gaps:73/401 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   117 EKVTMQNLNDRLASYLDKVRALEEANADLEVKI---RDWYQRQRPSEIKDYSPYFKTIEDLRNKI 178
            ||..:|:||||||.|:|::|.||..|:.|..::   :|...|: .|.:|  :.|.|.:...|..:
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRE-TSNLK--AVYEKELAAARKLL 107

Human   179 IAATIENAQPILQID---------------------------NARLAADDFRT---KYEHELALR 213
            .....|.|:  |:||                           ||||..:.:..   ||...||.|
  Fly   108 DETAKEKAK--LEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADR 170

Human   214 QTVE-------ADVNGLRRVLDEL-------TLARTDLEMQIEGLKEELAYLRKNHEEEMLALRG 264
            :..|       .:...|||.||:|       ||||.|||.|.:.|:||||:..:.|.:|:...|.
  Fly   171 KKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRS 235

Human   265 QTGGDVNVEMDAAPG-------VDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASN 322
            :.    .:|:....|       ..|.:.|.|:|||||.....||.:.|  .|...|..|.:.|:|
  Fly   236 RR----QIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIE--LLYDNEIQNLKAAAN 294

Human   323 SELVQS--SRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQ 385
            .....|  :..||..:|..:.||..:||:.....|.|...:.|.:.....:..:....|.|:|.:
  Fly   295 RAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAE 359

Human   386 LAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQA------SGQSYSSREVF 444
            |.::|.||..|.||||.|:|:|..|:.|||.|.:||.||:..|:.:..      ||.|.:...:.
  Fly   360 LQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLT 424

Human   445 TSSSSSSSRQT 455
            .|:||.|.|.|
  Fly   425 ASASSRSGRVT 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT16NP_005548.2 Head 1..116
Filament 116..427 CDD:278467 113/365 (31%)
Coil 1A 117..152 16/37 (43%)
Linker 1 153..170 4/16 (25%)
Coil 1B 171..262 37/134 (28%)
Zinc_peptidase_like <239..327 CDD:301362 27/94 (29%)
Linker 12 263..285 4/28 (14%)
Coil 2 286..424 48/139 (35%)
Tail 425..473 10/37 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..473 10/34 (29%)
LamCNP_001260974.1 Filament 45..401 CDD:278467 113/365 (31%)
ATP-synt_B <67..>142 CDD:304375 16/79 (20%)
MreC <178..>224 CDD:302802 19/45 (42%)
LTD 473..574 CDD:279300
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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