DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment itga5 and scb

DIOPT Version :9

Sequence 1:	NP_001004288.2	Gene:	itga5 / 386787	ZFINID:	ZDB-GENE-031116-52	Length:	1053	Species:	Danio rerio
Sequence 2:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster

Alignment Length:	1211	Identity:	297/1211 - (24%)
Similarity:	469/1211 - (38%)	Gaps:	316/1211 - (26%)

- Green bases have known domain annotations that are detailed below.

Zfish    13 STSCSPMGLSLLILLPLSVAFNLDVENPAVYNGPS----------GSYFGYSVDFYMTDSSVSII 67
            ||....:.|:||.|:....|||.......|.|.|.          .|||||::....|    |||
  Fly     5 STMFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQT----SII 65

Zfish    68 VGAPKANT---SQPKITEGGSVFYCPWSLSQSQCSSIEFDRLGDLNMSVNDTDHQGEFKSHQWFG 129
            ||||:|.:   ||..|.|.|:::.|  ||:...||....|..|:::...::.....|.|..||.|
  Fly    66 VGAPRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLG 128

Zfish   130 ATV---RVHQDSVLACAP-LYSWRTKEDTPHADTTGSCFM---SVKNFTKFV-EYAPCR------ 180
            .::   ....|.:|.||| .|:..::::..|    |.|:.   :|.:..:.| ..:|.|
  Fly   129 GSMDGGTKDTDKLLVCAPRFYAPSSRDNHLH----GVCYWVNNTVASTPQHVTRISPLRLKSEQV 189

Zfish   181 -TEFRGRKGQ-GYCQG--GFSADFTQEG-KVVLGGPGSYFWQGQVI-----------TAFKQEIV 229
             .|..|.|.. .|..|  |.||....:. |.::|.||...|:|.||           ||.:::..
  Fly   190 KEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTS 254

Zfish   230 KA------------YYPGYFLTSV-----GGQIQTKQRKEIRFDDTYMGYSVAVGEFTGDDDED- 276
            ||            |.|.::...:     .||          .:|:|.||:|:.|.|...:...
  Fly   255 KALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ----------EEDSYFGYAVSSGFFDSSNPTKL 309

Zfish   277 -FVTGVPRGVRLHGQVSILN---SSLDVLKMFTGEQMGSYYGYSVAATDINNDGMMDLLVGAPMF 337
             :|...|:..:..|:..|.:   .|:....:|.|||.|.|:||||.|.|:|.||..|::|.||..
  Fly   310 LYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQH 374

Zfish   338 MVRDSDGRLEELGRVYVYMQKGPLDLIPQLPHLTGTQMFARFGSSITPLGDLNQDGYNDVAISSP 402
            .:.||    .:.|.:||::.||..:...|:.. :..:..||||::::.|||:|.|||||||:.:|
  Fly   375 ALEDS----HDNGAIYVFINKGFFNFERQILR-SPVETMARFGTALSRLGDINHDGYNDVAVGAP 434

Zfish   403 FGGEDKQGLVLIYNGNAGGLREKPSQVISGQWASAGLSAIPAS-----FGYALRGGKDLDNNGYP 462
            |.|   .|.|.||.|:..|||::|||.:...      |..|:.     ||:.|..|.|:|.||:.
  Fly   435 FAG---NGTVFIYLGSENGLRDQPSQRLDAP------SQQPSKYGSHMFGHGLSRGSDIDGNGFN 490

Zfish   463 DLIVGAFGADKAVLYRSRPIVNTSAILNVYPIMINPEEKVCAISRGNETLHVSCVNLSFCLSANG 527
            |..:||..|:...|||:.|:|...|.:......|.||::...|:        :|..||
  Fly   491 DFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKIT--------ACYRLS------- 540

Zfish   528 KHLPNHLEFNVEVQLDRLKQQQKGAVR--------RALFLETQLPALHRTLTVPNGARVCSDTKI 584
                       ....|:|.|:|:.|:|        |..|.:||...:...:.. |....|.|.:.
  Fly   541 -----------TTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNA-NFGEQCRDFET 593

Zfish   585 YLR-DEKDFRDKLSPIFVALNFSLNPQAAADRHGLQ--PILNYQTAELIEQKAQILLDCGEDNIC 646
            .:| .|||.   .:||.:.:::.|..:........:  .|::....::..|.......|..| :|
  Fly   594 QVRYSEKDI---FTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VC 654

Zfish   647 VPDLKLSVHGDRKEVYMGDDNSLTLTFNAKNDGGGAYEAELYVVLPPEADYSGIARNNESLTQLT 711
            ..||:|..........:|..::|.|.:...|.|..||..:..|.......::.:..|.:.:..:
  Fly   655 TADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDAV- 718

Zfish   712 CSYETENQTRYLSCDL--GNPMKSGTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNEN---NSQS 771
                       :.|||  |.|:..|.:....:.|.|.:|......:..::......:|   |.|:
  Fly   719 -----------MVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQT 772

Zfish   772 EVVPYK--LEV-----VVRSDVILQGVSRPDKVFFPPPNWKLTKNVMVEQNVGPSVQHTYELVNN 829
            .|:..|  .|:     ...|.:.|:..|.                       ...:.:.||:.:|
  Fly   773 NVIGLKEFTEIDASGGQTNSQIDLEHYSN-----------------------SAEIVNNYEIKSN 814

Zfish   830 GPSRISHTLLQLKCPM--RLHSNRFIYPLEVTTEGPVNCTTHNIINPLNLKLQQSSTEQ------ 886
            |||.|....:....|:  ::..:..|.|               |||..:||:|.|...|
  Fly   815 GPSVIEQLTVSFYIPIAYKVAGSTAIIP---------------IINVTSLKMQASYDSQLLSIDL 864

Zfish   887 ----------PPV------------------------RDSGHEHH-IEKRDTHKGELSQLTNLSC 916
                      .||                        ..|||.|. :|..||   .:....::|.
  Fly   865 YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDT---SMVATASMSR 926

Zfish   917 SSVDCWTLMCNVGLLERGTSAILHVRSRIWAETFMENTYK-------NFILEC------------ 962
            ...|...|..|     |...|.:   |.:.|...:.:.:|       ..:..|
  Fly   927 KRRDLKALTAN-----REQYARI---SNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAE 983

Zfish   963 -HASYKVEK-----MPY--------AIL--------------------PKVTPSGSKKMVTPVVW 993
             ...::.||     |.|        |||                    |..|.....:.:.|.:.
  Fly   984 MRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNII 1048

Zfish   994 NKPDSSYAVPLWIIILAILAGLLLLALLIYVLYKLGFFKRT 1034
            :|...: .:|:||||::::.|||||:.:.|:|||.|||.||
  Fly  1049 SKHQET-GLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRT 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
itga5	NP_001004288.2	Int_alpha	47..104	CDD:214549	24/69 (35%)
		VCBS	269..332	CDD:290251	22/67 (33%)
		Int_alpha	309..>357	CDD:214549	20/47 (43%)
		Int_alpha	375..430	CDD:214549	29/54 (54%)
		Int_alpha	446..>484	CDD:214549	16/37 (43%)
		Integrin_alpha2	479..926	CDD:285619	95/512 (19%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	24/57 (42%)
		FG-GAP	350..388	CDD:280083	17/41 (41%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	72/387 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740