Protein Alignment PVRAP and TNS3

DIOPT Version :10

• Sequence 1: NP_729124.1
• Gene: PVRAP / 38677
• FlyBaseID: FBgn0052406
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_047276679.1
• Gene: TNS3 / 64759
• HGNCID: 21616
• Length: 1575
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 117/526 - (22%)
• Similarity: 184/526 - (34%)
• Gaps: 196/526 - (37%)

  Fly   110 VLTGAGARFRSSSCSNRHPAGVANPAVLRSPLATISRKTSLATPP---------SPAS--LGRRR 163
            ::.|.....:.|.||.  ||...:|   .:|..    ||:|..||         ||||  .|.|.
Human   959 IIDGRILSSKESMCST--PAFPVSP---ETPYV----KTALRHPPFSPPEPPLSSPASQHKGGRE 1014

  Fly   164 PL---QLFTHANLNCNDNEKVAQTP--------SSDEDNSPT----ELNSCKRLADKPPLVKRLT 213
            |.   :..|||       ..::::|        .:|..::|:    ..:||...::.|...:..:
Human  1015 PRSCPETLTHA-------VGMSESPIGPKSTMLRADASSTPSFQQAFASSCTISSNGPGQRRESS 1072

  Fly   214 MGLLRQNEESRP-----LVGDMTPLSAPL------------------------------------ 237
            ....||..||.|     |:|...|..:||
Human  1073 SSAERQWVESSPKPMVSLLGSGRPTGSPLSAEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEP 1137

  Fly   238 --DIQPVYSNGYI-------------NED--SYIDSKFGDSCRQS--LTAIPMLDNVNLNDNNEF 283
              .:.|..|..::             .||  :.:.:..|.|...|  |||....||..|:.|
Human  1138 PDSLAPPSSQAFLGFGTAPVGSGLPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHN--- 1199

  Fly   284 NLKKRYLRET--SSANSSPKIFANRLRM---------NQGAVGQRC-----------------SS 320
                 :|...  .|::.||.:....:.:         .:.:.|.|.                 |:
Human  1200 -----FLTVAPGHSSHHSPGLQGQGVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGST 1259

  Fly   321 LANAFGNVGSD-----EEDLELKDA----------------CWYQAGISRDIAVEVLQSKSPGAF 364
            ::..|.||..|     |....|.|:                .||:|.|||:.|:.:|:.|.||:|
Human  1260 ISIPFPNVLPDFSKASEAASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSF 1324

  Fly   365 LVRKSSSKPGCYALTLRVPSPP--------------GPKIANYIILRSPRGYKIKGFRKE--FSS 413
            :||.|.|..|.|.|.::|.:||              ...:.:::|..:|:|.::||...|  |.|
Human  1325 IVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGS 1389

  Fly   414 LKALITHHSVMPELLPVPLAMPRPTNMSSSRRNLDDF------DTYDSLQMLLK--------YLR 464
            |.||:..||:.|..||..|.:|       .|..|::.      ...:|...|||        ||.
Human  1390 LTALVCQHSITPLALPCKLLIP-------ERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLN 1447

  Fly   465 AKNMET 470
            :..||:
Human  1448 SVEMES 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVRAP	NP_729124.1	SH2	342..435	CDD:472789	39/108 (36%)
TNS3	XP_047276679.1	C1_TNS3_v	49..104	CDD:410439
		PTP_tensin-3	138..296	CDD:350409
		PTEN_C2	303..429	CDD:463081
		PHA03247	<754..1188	CDD:223021	48/244 (20%)
		SH2_Tensin_like	1298..1414	CDD:198181	40/122 (33%)
		PTB_tensin	1438..1569	CDD:269924	4/16 (25%)