Protein Alignment PVRAP and SH2D5

DIOPT Version :10

• Sequence 1: NP_729124.1
• Gene: PVRAP / 38677
• FlyBaseID: FBgn0052406
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001096631.1
• Gene: SH2D5 / 400745
• HGNCID: 28819
• Length: 423
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 74/321 - (23%)
• Similarity: 118/321 - (36%)
• Gaps: 75/321 - (23%)

  Fly   153 PPSPASLGRRRPLQLFTHANLNCNDNEKVAQTPSSDEDNSPTELNSCKRLADKPPLVKRLTMGLL 217
            |.||||       :||.|..:.                :.|.|:.....|     |.:...:..|
Human   111 PRSPAS-------KLFCHLFVG----------------SQPGEVQILHLL-----LCRSFQLAYL 147

  Fly   218 RQNEESRPLVGDMTPLSAP---LDIQPVYSNGYINEDSYIDSKFG-DSCRQSLTAIPMLDNVN-- 276
            .|:.|.|   ....|...|   :.::|:.|:|     ..:...|| |...|::.|:.....:.
Human   148 LQHPEER---AQPEPCPGPTGEVPLKPLSSSG-----GLVREPFGRDQLSQNVHALVSFRRLPAE 204

  Fly   277 --LNDNNEFNLKKRYLRETSSAN--SSPKIF---ANRLRMNQGAVGQRCS-------SLANAF-- 325
              :....|....:...|.....|  .||.:.   |.|.::.:....:.|:       |...||
Human   205 GLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPA 269

  Fly   326 ----------GNVGSDEEDLELKDACWYQAGISRDIAVEVLQSKSPGAFLVRKSSSKPGCYALTL 380
                      |:....|.:..|.:..|..|||||..|:.:|:....||||:.......|.:.|::
Human   270 AWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSV 334

  Fly   381 RVPSPPGPKIANYIILRSPRG-YKIKGFRKEFSSLKALITHHSVMPELLPVPLAMPR--PT 438
            |......|    :.:.|:..| |.::....||.||:||:.:|:|....|..||.|.|  ||
Human   335 RTQCGVVP----HQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLDMGRLNPT 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVRAP	NP_729124.1	SH2	342..435	CDD:472789	30/93 (32%)
SH2D5	NP_001096631.1	PTB_tensin-related	23..150	CDD:269979	13/66 (20%)
		SH2	296..372	CDD:198173	25/79 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..423		74/321 (23%)