Protein Alignment PVRAP and Tns1

DIOPT Version :10

• Sequence 1: NP_729124.1
• Gene: PVRAP / 38677
• FlyBaseID: FBgn0052406
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_006495930.2
• Gene: Tns1 / 21961
• MGIID: 104552
• Length: 1922
• Species: Mus musculus
• Alignment Length: 577
• Identity: 132/577 - (22%)
• Similarity: 200/577 - (34%)
• Gaps: 183/577 - (31%)

  Fly    21 SASSTIIAGATSTTAGTAATSVA--------------MSNRNGSTSSSSNSSPTADNSN----SN 67
            |.||.|:: |.||:.|:..:.|:              .|.|:||....|.::.:..:|:    ..
Mouse  1266 STSSPILS-ADSTSVGSFPSVVSSDQGPRTPFQPMLDSSIRSGSLGQPSPAALSYQSSSPVPVGG 1329

  Fly    68 SNSNSNANINRNLNQNPNS-------------------------NSNTNSNSYFNRFDNRIAANL 107
            |:.||.....:..:.:|.|                         .:||..:..|.|  ..:...:
Mouse  1330 SSYNSPDYSLQPFSSSPESQGQPQYSAASVHMVPGSPQARHRTVGTNTPPSPGFGR--RAVNPTM 1392

  Fly   108 AA----------VLTGAGARFRSSSCSNRHPAGVA----NPAVLRSPLAT---ISRKTSLATPPS 155
            ||          |:..:|..|..:..|. |||..|    :|::.|.|:.:   ....:|:.|.|.
Mouse  1393 AAPGSPSLSHRQVMGPSGPGFHGNVVSG-HPASAATTPGSPSLGRHPVGSHQVPGLHSSVVTTPG 1456

  Fly   156 PASLGRRRPLQLFTHANLNCNDNEKVAQTPSSDEDNSPTELNSCKRLADKPPLVKRLTMGLLRQN 220
            ..||||.                      |.:.:.|..:.|:|...::...|.:.|...|
Mouse  1457 SPSLGRH----------------------PGAHQGNLASSLHSNAVISPGSPSLGRHLGG----- 1494

  Fly   221 EESRPLVGDMTPLSAPLDIQPVYSNGYINEDSYIDSKFGDSCRQSLTAIPMLDNVNLNDNNEFNL 285
                  .|.:.|.|..||....|......||.          |.:|:...............|.:
Mouse  1495 ------SGSVVPGSPSLDRHAAYGGYSTPEDR----------RPTLSRQSSASGYQAPSTPSFPV 1543

  Fly   286 KKRYLRETSSANSSPKIFANRLRMNQG------------AVGQRCSSLAN--------------- 323
            ...|....||..:||.  .:.....||            :||.|..||.|
Mouse  1544 SPAYYPGLSSPATSPS--PDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVAN 1606

  Fly   324 ---------AFGNVGSDEEDLELKD----------------ACWYQAGISRDIAVEVLQSKSPGA 363
                     :|.:...|.....:.|                ..||:..|||:.|:.:|:.:.|||
Mouse  1607 GMASGSSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGA 1671

  Fly   364 FLVRKSSSKPGCYALTLRVPSPP------GPK-------IANYIILRSPRGYKIKGFRKE--FSS 413
            |::|.|.|..|.|.|.::|.|||      |.|       :.:::|...|||.|:||...|  |.|
Mouse  1672 FIIRDSHSFRGAYGLAMKVSSPPPTITQQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGS 1736

  Fly   414 LKALITHHSVMPELLPVPLAMPR--PTNMSSSRRNLDDFDTYDSLQMLLKYLRAKNM 468
            |.||:..|||:|..||..|.:|.  ||:.|.     |.....:|...|||...|.|:
Mouse  1737 LSALVYQHSVIPLALPCKLVIPSRDPTDESK-----DSSGPANSTTDLLKQGAACNV 1788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVRAP	NP_729124.1	SH2	342..435	CDD:472789	43/107 (40%)
Tns1	XP_006495930.2	C1	61..116	CDD:412127
		PTP_DSP_cys	189..347	CDD:475123
		PTEN_C2	354..480	CDD:463081
		PHA03247	<737..1233	CDD:223021
		PHA03247	<1073..1649	CDD:223021	78/431 (18%)
		SH2_Tensin_like	1646..1761	CDD:198181	44/114 (39%)
		PTB_tensin	1783..1916	CDD:269924	2/6 (33%)