Protein Alignment PVRAP and tns-1

DIOPT Version :10

• Sequence 1: NP_729124.1
• Gene: PVRAP / 38677
• FlyBaseID: FBgn0052406
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_491637.2
• Gene: tns-1 / 172215
• WormBaseID: WBGene00006508
• Length: 1354
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 120/545 - (22%)
• Similarity: 190/545 - (34%)
• Gaps: 161/545 - (29%)

  Fly    45 SNRNGSTSSSSNSSPTADNSNSNSNSNSNANINRNLNQNPNS------NSNTNS-----NSYFNR 98
            :.|.||..|..:............|::::.|.:..||..|..      |.|..|     |.:|:.
 Worm   681 TKRLGSAYSVGDVRGGQQQQQEQHNASNDFNFSNTLNNTPTDYRQHYRNRNCQSVTTPRNHHFST 745

  Fly    99 FDNRIAANLAAV-LTGAGARFRS---------------------------SSCSNRH--PAGVAN 133
            ......|:.|.. |:|...:.||                           ::..|:|  |.|.|.
 Worm   746 PSREQEADAADTWLSGKLKKVRSKRDIDPDIVRRRTQEKMLLEELKDSAANNDENQHNLPNGHAR 810

  Fly   134 PAVLRS--PLATISRKTS------------------LATPPSPA----------SLGRRRPLQLF 168
            .|.|::  |||...|:..                  ...||:|.          ||.|..|
 Worm   811 GAGLQNIDPLAEFRREEERLRNTRSPYGEERWRGRMRGKPPTPPPRESSASPVNSLPRGTP---- 871

  Fly   169 THANLNCNDNEKVAQTPSSDEDNSPTELNSCKRLADKPPLVKRLTMGLLRQNEESRPLVGDMTPL 233
            .|.......|:.|.......:.:...::||....:..|             .::|..|......|
 Worm   872 AHHMDRQRHNQSVPLPMHHRQFDEDFDVNSLFNFSHDP-------------RQQSTTLERGGRSL 923

  Fly   234 SAPLDIQPVYSNGYIN-EDSYIDSKFGDSCRQSLTAIPMLDNVNLN-----DNNEFNLKKRYLRE 292
            |....||..|   |.: :|...:::|.....:...||...:..:.:     ..|......||..|
 Worm   924 SRGARIQDAY---YASQQDLSANNRFNSGQERVAAAIYRAETAHRDMYASGTINRAETPGRYFPE 985

  Fly   293 TSSA---NSSPKIFANR--------LRMNQGAVG-------------------QRCSSLANAFG- 326
            .|:.   :|:|....:|        |..|.|..|                   ...|:....||
 Worm   986 NSAVLERSSTPSFPVSRATPLPFHPLLYNNGERGGSGHAAGGGGGGHNGYSTMNNRSASPRLFGG 1050

  Fly   327 -----------NVGSDE----EDLELKDAC--WYQAGISRDIAVEVLQSKSPGAFLVRKSSSKPG 374
                       :|.:.|    ..|.:||..  ||:..|||:.|:.:|:.|.||.|:||.|:|.||
 Worm  1051 SSTLSRRSSVNSVDTSEIIHHHPLFVKDTSKYWYKPTISREQAINMLRDKPPGTFVVRDSNSFPG 1115

  Fly   375 CYALTLRVPSPP-------GPKIANYIILR-SPRGYKIKGFRKE--FSSLKALITHHSVMPELLP 429
            .:.|.|:|.:||       |.::..:.::. ||:|.|:||...|  |.||.||:..||:....||
 Worm  1116 AFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALP 1180

  Fly   430 VPLAMP------RPTNMSSSRRNLD 448
            ..|.:|      .|.::|:::..|:
 Worm  1181 TKLVLPDFDPAATPEHLSATQALLE 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVRAP	NP_729124.1	SH2	342..435	CDD:472789	40/102 (39%)
tns-1	NP_491637.2	PTP_tensin	46..203	CDD:350358
		SH2_Tensin_like	1079..1189	CDD:198181	41/109 (38%)
		PTB_tensin	1207..1348	CDD:269924