Protein Alignment PVRAP and tns3

DIOPT Version :10

• Sequence 1: NP_729124.1
• Gene: PVRAP / 38677
• FlyBaseID: FBgn0052406
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_031760312.1
• Gene: tns3 / 100492216
• XenbaseID: XB-GENE-1011198
• Length: 1408
• Species: Xenopus tropicalis
• Alignment Length: 656
• Identity: 129/656 - (19%)
• Similarity: 223/656 - (33%)
• Gaps: 228/656 - (34%)

  Fly     8 TMITNNN------LDYDQA----------------------SASSTIIAGATSTTAGTAATSVAM 44
            |.|||::      ||.||:                      :.|||:.:...:..:|..
 Frog   667 TEITNHDFPSSPTLDIDQSIEQLNKLILELDPTFEPIPTRINTSSTVESSLNAILSGDL------ 725

  Fly    45 SNRNGSTSSSSNSSPTADNSNSNSNSNSNANI--NRNLNQNPNSNSNTNSNSY----FNRFDNRI 103
             .::|....|...:....:|....:...:|::  .|.|:.....|.||:...|    :.....:|
 Frog   726 -EKDGILLQSPLEAKQGGDSFQEGSKKGSASLAAARKLSFGQYDNGNTDPLQYCSYGWKTSPEQI 789

  Fly   104 AANLAAVLTG----------AGARFRSSSCSNRHPAGVANPAVLRSPLATISRKTSLATPPSPAS 158
            |:.....|.|          .|......:..:|...||               :|...||..|.|
 Frog   790 ASTKTLPLIGHSKEGHTLHYQGQYDEVDNIFSRSSQGV---------------ETVPPTPSFPVS 839

  Fly   159 ---------LGRRRPLQLFTH--------------ANLNCNDNEKVAQTPSSDEDNSPTELNSCK 200
                     |...:|.:...|              :|.:.:.::.|.::.:|.:.||...:...:
 Frog   840 PDTPYVRTHLSYSQPHEEGYHTPHLTEILHLGGDTSNYSESRHQTVLESVTSSDLNSSLCMTEMQ 904

  Fly   201 RLADKPPLVKRLTMGLLRQNEE-------------------SRPLVGDMTPLSAPLDIQ---PVY 243
            |     |.|.:|:..:..:.::                   |:|.:...:.::.||..:   |:.
 Frog   905 R-----PTVPKLSNAVFSRRDDCSLDNENFWLENSPTPLLSSQPSLKSRSQVNCPLSTEYPNPMV 964

  Fly   244 SNGYINEDSYI--------DSKFGDSCRQSLTAIPMLD-NVNLNDNNEFNLKKRYLRETSSANSS 299
            ....:.:::.:        :.:|..|..|.:.|.|.|. |.:...||...|.:|::...||...|
 Frog   965 EKSVLTQETTLSLEALTICNPEFASSNSQDILANPHLYLNFDGTGNNLPLLDERHVAFMSSTKGS 1029

  Fly   300 PKI------------------------------FANRLRMNQG--------------AVGQRCSS 320
            ||:                              ...:.|:::|              :.....|:
 Frog  1030 PKVGRSADSAINSKEQRSPFLQRSGKKKYSHPPLPEKKRISEGEHSFGSISPSSSGFSSPNSGST 1094

  Fly   321 LANAFGNV---------------GSDEEDLELK-----DACWYQAGISRDIAVEVLQSKSPGAFL 365
            ::..|.||               .|.::.:.:|     ...||:..||||.|:.||:.|.||:|:
 Frog  1095 ISIPFPNVLPDFSQVISEFPVSENSSDKHMTVKFVQDTSKFWYKPDISRDQAIAVLKDKEPGSFI 1159

  Fly   366 VRKSSSKPGCYALTLRVPSPP---------GPKIAN-----YIILRSPRGYKIKGFRKE--FSSL 414
            ||.|.|..|.|.|.::|.:||         |..:.|     ::|....:|.::||...|  |.||
 Frog  1160 VRDSHSFKGAYGLAMKVATPPPSVLHSSKKGLDLTNELVRHFLIECVHKGVRLKGCPNEPYFGSL 1224

  Fly   415 KALITHHSVMPELLPVPLAMPR-------PTNMSSSRRNLDDFDTYDSLQMLLK--------YLR 464
            .||:..||:.|..||..|.:|.       |.....|..|        |...|||        ||.
 Frog  1225 TALVYQHSITPLALPCKLLIPDKDPLEEIPAATPQSAAN--------SAAELLKQGAACNVWYLN 1281

  Fly   465 AKNMET 470
            :..||:
 Frog  1282 SVEMES 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVRAP	NP_729124.1	SH2	342..435	CDD:472789	41/108 (38%)
tns3	XP_031760312.1	PTP_tensin-3	12..170	CDD:350409
		PTEN_C2	177..300	CDD:463081
		SH2_Tensin_like	1132..1248	CDD:198181	42/115 (37%)
		PTB_tensin	1272..1402	CDD:269924	4/16 (25%)