DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and IMPA-7

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001319482.1	Gene:	IMPA-7 / 819741	AraportID:	AT3G05720	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	396	Identity:	113/396 - (28%)
Similarity:	193/396 - (48%)	Gaps:	20/396 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VNKLLKSNTIGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVPRLIRLLQSPDP 119
            |.:::::..:...||.|...:..:::.:||.||.:||||:||::.::...|||..|:|||.||..
plant    96 VEEVIQAGLVPRFVEFLTWDDSPQLQFEAAWALTNIASGTSENTEVVIDHGAVAILVRLLNSPYD 160

  Fly   120 EVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLMSIIQDKSTCTLMLSHVTWVLRKLCISSQPSP 184
            .|.|:.:.:|||:...:|..||.::.|..:..|:..:...:..: ||.:..|.|..|| ..:|.|
plant   161 VVREQVVWALGNISGDSPRCRDIVLGHAALPSLLLQLNHGAKLS-MLVNAAWTLSNLC-RGKPQP 223

  Fly   185 P-DNAAEIIQALNIVLYNPEANVLEDALMAVRNLAHG-NETIQMLLDFEVVPRIIYLLEHPNVTV 247
            | |..:..:.||..::...:..:|.....|:..|:.| ||.||.:::..|..|:|.|..|.:.:|
plant   224 PFDQVSAALPALAQLIRLDDKELLAYTCWALVYLSDGSNEKIQAVIEANVCARLIGLSIHRSPSV 288

  Fly   248 QNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNS-DPDIRCQVLKLLLNIADGNIFQRHAI 311
            ...||:.:.||.||::.|.|.:::...||.|..|:..| :..||.:....:.||..|...|..|:
plant   289 ITPALRTIGNIVTGNDSQTQHIIDLQALPCLVNLLRGSYNKTIRKEACWTVSNITAGCQSQIQAV 353

  Fly   312 MNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFCNLLFCQERDILS 376
            .:|.:...::..|:.....:|..||..|...........:.:|::|..|...|:||.|.:..::.
plant   354 FDADICPALVNLLQNSEGDVKKEAAWAICNAIAGGSYKQIMFLVKQECIKPLCDLLTCSDTQLVM 418

  Fly   377 NVLDILSTMLDVDPSFSA-EVSGI--------------IEWSGALNNIRMLQSSEHEEIAAVARK 426
            ..|:.|..:|.|...||: ...||              ||.:..|..|..|||.|:.:|...|.|
plant   419 VCLEALKKILKVGEVFSSRHAEGIYQCPQTNVNPHAQLIEEAEGLEKIEGLQSHENNDIYETAVK 483

  Fly   427 IIGNYF 432
            |:..|:
plant   484 ILETYW 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	36/119 (30%)
		armadillo repeat	98..134	CDD:293788	14/35 (40%)
		armadillo repeat	140..176	CDD:293788	8/35 (23%)
		ARM	189..301	CDD:237987	32/113 (28%)
		armadillo repeat	192..217	CDD:293788	4/24 (17%)
		armadillo repeat	224..260	CDD:293788	12/35 (34%)
		armadillo repeat	266..300	CDD:293788	8/34 (24%)
		ARM	276..385	CDD:237987	26/109 (24%)
		armadillo repeat	308..342	CDD:293788	7/33 (21%)
		armadillo repeat	350..383	CDD:293788	8/32 (25%)
		Arm_3	400..>433	CDD:292804	13/33 (39%)
IMPA-7	NP_001319482.1	SRP1	24..489	CDD:227396	112/394 (28%)
		armadillo repeat	62..86	CDD:293788
		armadillo repeat	99..131	CDD:293788	7/31 (23%)
		armadillo repeat	139..175	CDD:293788	14/35 (40%)
		armadillo repeat	181..216	CDD:293788	8/35 (23%)
		armadillo repeat	232..257	CDD:293788	4/24 (17%)
		armadillo repeat	265..301	CDD:293788	12/35 (34%)
		armadillo repeat	307..342	CDD:293788	8/34 (24%)
		armadillo repeat	350..387	CDD:293788	7/36 (19%)
		armadillo repeat	393..427	CDD:293788	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920