Protein Alignment alphaKap4 and KPNA5

DIOPT Version :10

• Sequence 1: NP_648007.1
• Gene: alphaKap4 / 38675
• FlyBaseID: FBgn0035657
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001353233.1
• Gene: KPNA5 / 3841
• HGNCID: 6398
• Length: 559
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 120/401 - (29%)
• Similarity: 205/401 - (51%)
• Gaps: 17/401 - (4%)

  Fly    45 KLTSSEVVPDVNKLL-KSNTIGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVP 108
            ||.|.|..|.::::: |...:...|:.|.......::.:||.||.:||||:..|:.::.:.||||
Human   129 KLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVP 193

  Fly   109 RLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLMSIIQDKSTCTLMLSHVTWVL 173
            ..|:||.|...:|.|:.:.:|||:.......||:::...::..|:.::.:.:..|...:.| |.|
Human   194 IFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAV-WAL 257

  Fly   174 RKLCISSQPSPPDNAAEIIQALNI---VLYNPEANVLEDALMAVRNLAHG-NETIQMLLDFEVVP 234
            ..||...  :||.|.:::...||:   :|::.:.:||.|...|:..|:.| |:.||.::|..|..
Human   258 SNLCRGK--NPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 320

  Fly   235 RIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNSDPDIRCQVLKLLLN 299
            |::.||.|.:..|.:.||:|:.||.||.:.|.|.:||.:.||.|..|:|:....||.:....:.|
Human   321 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSN 385

  Fly   300 IADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFC 364
            |..||..|..|:::|.:...::|.|:......:..||..||..........:.||:..|.|...|
Human   386 ITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLC 450

  Fly   365 NLLFCQERDILSNVLDILSTMLDVDPSFSAEVSGI--------IEWSGALNNIRMLQSSEHEEIA 421
            :||...:..|:...|:.|..:|.:....|.: :||        ||.:..|:.|..|||.|::||.
Human   451 DLLTVMDSKIVQVALNGLENILRLGEQESKQ-NGIGINPYCALIEEAYGLDKIEFLQSHENQEIY 514

  Fly   422 AVARKIIGNYF 432
            ..|..:|.:||
Human   515 QKAFDLIEHYF 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	SRP1	45..432	CDD:227396	118/399 (30%)
		armadillo repeat	98..134	CDD:293788	13/35 (37%)
		armadillo repeat	140..176	CDD:293788	7/35 (20%)
		armadillo repeat	192..217	CDD:293788	7/27 (26%)
		armadillo repeat	224..260	CDD:293788	14/35 (40%)
		armadillo repeat	266..300	CDD:293788	10/33 (30%)
		armadillo repeat	308..342	CDD:293788	8/33 (24%)
		armadillo repeat	350..383	CDD:293788	9/32 (28%)
KPNA5	NP_001353233.1	SRP1	56..541	CDD:227396	120/401 (30%)
		armadillo repeat	142..175	CDD:293788	7/32 (22%)
		armadillo repeat	183..219	CDD:293788	13/35 (37%)
		armadillo repeat	225..260	CDD:293788	7/35 (20%)
		armadillo repeat	277..302	CDD:293788	7/24 (29%)
		armadillo repeat	310..346	CDD:293788	14/35 (40%)
		armadillo repeat	354..386	CDD:293788	9/31 (29%)
		armadillo repeat	394..430	CDD:293788	8/35 (23%)
		armadillo repeat	437..471	CDD:293788	10/33 (30%)