DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and KPNA4

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_002259.1	Gene:	KPNA4 / 3840	HGNCID:	6397	Length:	521	Species:	Homo sapiens

Alignment Length:	477	Identity:	160/477 - (33%)
Similarity:	251/477 - (52%)	Gaps:	48/477 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRKRRFLKKGQNLMMLRTLR------LEKAKKAE--LQK-------------------------E 34
            :|.:.|..||::|..:|..|      |.|.|:.|  |::                         |
Human    10 QRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLE 74

  Fly    35 LTIYNALT------------KCKLTSSEVVPDVNKLLKSNTIGNLVESLGHGNKNKIRADAADAL 87
            ..:.||.:            ..||.||:..|.::.|:||..:..||..|...:...::.:||.||
Human    75 AIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWAL 139

  Fly    88 AHIASGSSEHSNLIAKAGAVPRLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKL 152
            .:||||:||.:..:.::.|||..:|||.||...|||:.:.:|||::...|..|||:|..|:::.|
Human   140 TNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPL 204

  Fly   153 MSIIQDKSTCTLMLSHVTWVLRKLCISSQPSPP-DNAAEIIQALNIVLYNPEANVLEDALMAVRN 216
            :|.|......| .|.:||||:..||....|.|| :...||:.||.:::::.:.|:|.|.:.|:..
Human   205 LSFISPSIPIT-FLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSY 268

  Fly   217 LAH-GNETIQMLLDFEVVPRIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSA 280
            |.. |||.|||::|..:||.::.||.|..|.||.|||:|:.||.||::||.|.:||.:.|.|..|
Human   269 LTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPA 333

  Fly   281 LMSNSDPDIRCQVLKLLLNIADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAID 345
            |:::....|..:.:..|.||..||..|..|:::|.|:..|:..|.......:..||..|:.|.|.
Human   334 LLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTIS 398

  Fly   346 KDKNLLCYLMRQGVIPEFCNLLFCQERDILSNVLDILSTMLDVDPSFSAEVSGIIEWSGALNNIR 410
            ..|:.:.||::|.|||.|||||..::..::..|||.||.:|.:....:..:..:||..|.|..|.
Human   399 GRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIE 463

  Fly   411 MLQSSEHEEIAAVARKIIGNYF 432
            .||:.|:|:|..:|.:||..:|
Human   464 QLQNHENEDIYKLAYEIIDQFF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	45/119 (38%)
		armadillo repeat	98..134	CDD:293788	14/35 (40%)
		armadillo repeat	140..176	CDD:293788	14/35 (40%)
		ARM	189..301	CDD:237987	44/112 (39%)
		armadillo repeat	192..217	CDD:293788	6/24 (25%)
		armadillo repeat	224..260	CDD:293788	18/35 (51%)
		armadillo repeat	266..300	CDD:293788	9/33 (27%)
		ARM	276..385	CDD:237987	37/108 (34%)
		armadillo repeat	308..342	CDD:293788	8/33 (24%)
		armadillo repeat	350..383	CDD:293788	14/32 (44%)
		Arm_3	400..>433	CDD:292804	14/33 (42%)
KPNA4	NP_002259.1	SRP1	11..513	CDD:227396	160/476 (34%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		2/8 (25%)
		ARM 1, truncated	66..106		7/39 (18%)
		armadillo repeat	73..98	CDD:293788	3/24 (13%)
		ARM 2	107..149		15/41 (37%)
		armadillo repeat	109..142	CDD:293788	10/32 (31%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		38/92 (41%)
		armadillo repeat	150..186	CDD:293788	14/35 (40%)
		armadillo repeat	192..227	CDD:293788	14/35 (40%)
		ARM 4	195..233		13/38 (34%)
		ARM 5	234..278		14/43 (33%)
		armadillo repeat	244..269	CDD:293788	6/24 (25%)
		ARM 6	279..318		18/38 (47%)
		armadillo repeat	279..311	CDD:293788	14/31 (45%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		29/87 (33%)
		armadillo repeat	319..355	CDD:293788	11/35 (31%)
		ARM 8	361..400		10/38 (26%)
		armadillo repeat	361..395	CDD:293788	8/33 (24%)
		ARM 9	401..443		18/41 (44%)
		armadillo repeat	404..438	CDD:293788	16/33 (48%)
		ARM 10, atypical	447..485		13/37 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810