DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and KPNA3

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_002258.2	Gene:	KPNA3 / 3839	HGNCID:	6396	Length:	521	Species:	Homo sapiens

Alignment Length:	476	Identity:	163/476 - (34%)
Similarity:	255/476 - (53%)	Gaps:	48/476 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RKRRFLKKGQNLMMLR------TLRLEKAKKAE--LQK-------------------------EL 35
            |.:.|..||:::..:|      |:.|.|.|:.|  |:|                         |.
Human    11 RIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEA 75

  Fly    36 TIYNALT------------KCKLTSSEVVPDVNKLLKSNTIGNLVESLGHGNKNKIRADAADALA 88
            .:.||.:            ..||.||:..|.::.|:||..:..||:.|...:...::.:||.||.
Human    76 ILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALT 140

  Fly    89 HIASGSSEHSNLIAKAGAVPRLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLM 153
            :||||:|..:..:.::.|||..:|||:||...|||:.:.:|||::...|..|||:|..|:::.|:
Human   141 NIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLL 205

  Fly   154 SIIQDKSTCTLMLSHVTWVLRKLCISSQPSPP-DNAAEIIQALNIVLYNPEANVLEDALMAVRNL 217
            |.|......| .|.:||||:..||.:..|.|| :...||:.||.:::|:.:.|:|.|.:.|:..|
Human   206 SFISPSIPIT-FLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYL 269

  Fly   218 AH-GNETIQMLLDFEVVPRIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSAL 281
            .. |||.|||::|..|||.::.||.|..|.||.|||:|:.||.||::||.|.:||.::|.|...|
Human   270 TDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNL 334

  Fly   282 MSNSDPDIRCQVLKLLLNIADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDK 346
            :|:....|..:.:..|.||..||..|..|:::|||:..|:..|.......:..||..|:.|.|..
Human   335 LSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISG 399

  Fly   347 DKNLLCYLMRQGVIPEFCNLLFCQERDILSNVLDILSTMLDVDPSFSAEVSGIIEWSGALNNIRM 411
            .|:.:.||::|.|||.|||||..::..::..|||.|..:|.:....::.::.|||..|.|..|.:
Human   400 RKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEV 464

  Fly   412 LQSSEHEEIAAVARKIIGNYF 432
            ||..|:|:|..:|.:||..||
Human   465 LQQHENEDIYKLAFEIIDQYF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	44/119 (37%)
		armadillo repeat	98..134	CDD:293788	14/35 (40%)
		armadillo repeat	140..176	CDD:293788	14/35 (40%)
		ARM	189..301	CDD:237987	46/112 (41%)
		armadillo repeat	192..217	CDD:293788	7/24 (29%)
		armadillo repeat	224..260	CDD:293788	19/35 (54%)
		armadillo repeat	266..300	CDD:293788	9/33 (27%)
		ARM	276..385	CDD:237987	37/108 (34%)
		armadillo repeat	308..342	CDD:293788	9/33 (27%)
		armadillo repeat	350..383	CDD:293788	14/32 (44%)
		Arm_3	400..>433	CDD:292804	15/33 (45%)
KPNA3	NP_002258.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		5/17 (29%)
		SRP1	2..521	CDD:227396	163/476 (34%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		3/8 (38%)
		ARM 1, truncated	66..106		7/39 (18%)
		armadillo repeat	73..98	CDD:293788	3/24 (13%)
		ARM 2	107..149		15/41 (37%)
		armadillo repeat	109..142	CDD:293788	10/32 (31%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		37/92 (40%)
		armadillo repeat	150..186	CDD:293788	14/35 (40%)
		armadillo repeat	192..227	CDD:293788	14/35 (40%)
		ARM 4	195..233		13/38 (34%)
		ARM 5	234..278		15/43 (35%)
		armadillo repeat	244..269	CDD:293788	7/24 (29%)
		armadillo repeat	277..313	CDD:293788	19/35 (54%)
		ARM 6	279..318		19/38 (50%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		30/87 (34%)
		armadillo repeat	319..353	CDD:293788	9/33 (27%)
		ARM 8	361..400		11/38 (29%)
		armadillo repeat	361..395	CDD:293788	9/33 (27%)
		ARM 9	401..443		17/41 (41%)
		armadillo repeat	404..438	CDD:293788	15/33 (45%)
		ARM 10, atypical	447..485		14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810