DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and KPNA1

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_002255.3	Gene:	KPNA1 / 3836	HGNCID:	6394	Length:	538	Species:	Homo sapiens

Alignment Length:	401	Identity:	117/401 - (29%)
Similarity:	200/401 - (49%)	Gaps:	17/401 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KLTSSEVVPDVNKLLKS-NTIGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVP 108
            ||.|.|..|.:::::.: ..:...||.|.......::.::|..|.:||||:|..:.::.:|||||
Human   108 KLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVP 172

  Fly   109 RLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLMSIIQDKSTCTLMLSHVTWVL 173
            ..|.||.|...:|.|:.:.:|||:...:...|||::...::..|:.:...::..| |..:..|.|
Human   173 IFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLT-MTRNAVWAL 236

  Fly   174 RKLCISSQPSPPDNAAEIIQALNI---VLYNPEANVLEDALMAVRNLAHG-NETIQMLLDFEVVP 234
            ..||...  |||...|::...||:   :|:..:.:||.||..|:..|:.| |:.||.::|..|..
Human   237 SNLCRGK--SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCR 299

  Fly   235 RIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNSDPDIRCQVLKLLLN 299
            |::.||.|.:..|.:.||:|:.||.||.:.|.|.:||.:.|..|..|:|:....|:.:....:.|
Human   300 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISN 364

  Fly   300 IADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFC 364
            |..||..|...:::|.:...::..|:......:..||..||..........:.||:..|.|...|
Human   365 ITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLC 429

  Fly   365 NLLFCQERDILSNVLDILSTMLDVDPSFSAEVSG--------IIEWSGALNNIRMLQSSEHEEIA 421
            :||...:..|:...|:.|..:|.:... .|:.:|        :||.:..|:.|..|||.|::||.
Human   430 DLLTVMDSKIVQVALNGLENILRLGEQ-EAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIY 493

  Fly   422 AVARKIIGNYF 432
            ..|..:|.:||
Human   494 QKAFDLIEHYF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	32/120 (27%)
		armadillo repeat	98..134	CDD:293788	14/35 (40%)
		armadillo repeat	140..176	CDD:293788	8/35 (23%)
		ARM	189..301	CDD:237987	38/115 (33%)
		armadillo repeat	192..217	CDD:293788	8/27 (30%)
		armadillo repeat	224..260	CDD:293788	14/35 (40%)
		armadillo repeat	266..300	CDD:293788	8/33 (24%)
		ARM	276..385	CDD:237987	25/108 (23%)
		armadillo repeat	308..342	CDD:293788	6/33 (18%)
		armadillo repeat	350..383	CDD:293788	9/32 (28%)
		Arm_3	400..>433	CDD:292804	14/33 (42%)
KPNA1	NP_002255.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Arm_3	33..516	CDD:330530	117/401 (29%)
		nuclear localization signal	42..51
		ARM 1, truncated	77..117		4/8 (50%)
		HEAT repeat	88..116	CDD:293787	4/7 (57%)
		ARM 2	118..161		10/42 (24%)
		armadillo repeat	128..154	CDD:293788	5/25 (20%)
		NLS binding site (major). /evidence=ECO:0000250	149..241		29/92 (32%)
		armadillo repeat	162..198	CDD:293788	14/35 (40%)
		armadillo repeat	204..239	CDD:293788	8/35 (23%)
		ARM 4	207..245		7/40 (18%)
		Binding to RAG1	245..437		57/191 (30%)
		armadillo repeat	256..281	CDD:293788	8/24 (33%)
		armadillo repeat	289..325	CDD:293788	14/35 (40%)
		NLS binding site (minor). /evidence=ECO:0000250	318..406		24/87 (28%)
		armadillo repeat	373..409	CDD:293788	6/35 (17%)
		ARM 9	413..457		11/44 (25%)
		armadillo repeat	416..450	CDD:293788	10/33 (30%)
		ARM 10, atypical	460..504		13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820