DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and Spag6

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001001334.2	Gene:	Spag6 / 381350	MGIID:	3040687	Length:	509	Species:	Mus musculus

Alignment Length:	358	Identity:	78/358 - (21%)
Similarity:	156/358 - (43%)	Gaps:	67/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IASGSSEHSNL--IAKAGAVPRLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKL 152
            :|..:::..|:  :..||.:..|..||....|.:.:...|:||.|.::..:|.:.:::..::.:|
Mouse    24 VAEQATKPQNIETLQNAGIMSLLRPLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKGDILPQL 88

  Fly   153 MSIIQDKSTCTLMLSHVTWVLRKLCISSQPSPPDNAAEI----IQALNIVLYNPEANVLEDALMA 213
            :..:.::: |....: ..:|||.:   .:.||....|.:    :.:|.|.|.:.:..|.|.|..|
Mouse    89 VYSLAEQN-CVYKKA-AAFVLRAV---GKHSPQLAQATVDCGALDSLVICLEDFDPGVKEAAAWA 148

  Fly   214 VRNLA-HGNETIQMLLDFEVVPRIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPH 277
            :..:| |..|..|.::|...||.::..::.|...::..|..||.:|:..|.|..|.:::...:.|
Mouse   149 LAYIARHNAELSQAVVDAGAVPLLVLCIQEPETALKRIAASALSDISKHSPELAQTVVDVGAIAH 213

  Fly   278 LSALMSNSDPDIRCQVLKLLLNIADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTL 342
            |:.::.|.|..::.|||..|.:||..::.....::.|.:...:|.|||
Mouse   214 LAQMILNPDEKLKQQVLSALSHIAKHSVDLAEMVVEAEIFPVVLTCLK----------------- 261

  Fly   343 AIDKD----KNLLCYLMRQGVIPEFCNLLFCQERDILSNVLDILSTMLDVDPSFSAEVSGIIEWS 403
              |||    ||.             |.|:    |:|..:..::...:::     :..|:.:|:..
Mouse   262 --DKDDFVKKNA-------------CTLI----REIAKHTPELSQLIVN-----AGGVAAVIDCI 302

  Fly   404 GAL-NNIR---------MLQSSEHEEIAAVARK 426
            |:. .|||         |...||:..:|.:..|
Mouse   303 GSCKGNIRLPGIMMLGYMAAHSENLAMAVIISK 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	18/88 (20%)
		armadillo repeat	98..134	CDD:293788	11/37 (30%)
		armadillo repeat	140..176	CDD:293788	5/35 (14%)
		ARM	189..301	CDD:237987	31/116 (27%)
		armadillo repeat	192..217	CDD:293788	7/24 (29%)
		armadillo repeat	224..260	CDD:293788	9/35 (26%)
		armadillo repeat	266..300	CDD:293788	9/33 (27%)
		ARM	276..385	CDD:237987	24/112 (21%)
		armadillo repeat	308..342	CDD:293788	5/33 (15%)
		armadillo repeat	350..383	CDD:293788	4/32 (13%)
		Arm_3	400..>433	CDD:292804	10/37 (27%)
Spag6	NP_001001334.2	armadillo repeat	34..70	CDD:293788	10/35 (29%)
		armadillo repeat	76..108	CDD:293788	3/33 (9%)
		armadillo repeat	127..152	CDD:293788	7/24 (29%)
		SRP1	<161..>423	CDD:227396	47/216 (22%)
		armadillo repeat	162..194	CDD:293788	7/31 (23%)
		armadillo repeat	202..238	CDD:293788	10/35 (29%)
		armadillo repeat	244..278	CDD:293788	13/69 (19%)
		HEAT repeat	335..369	CDD:293787	1/1 (100%)
		HEAT repeat	378..406	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900