DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and Kpna6

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001015029.2	Gene:	Kpna6 / 362607	RGDID:	1306570	Length:	541	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	126/404 - (31%)
Similarity:	209/404 - (51%)	Gaps:	23/404 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KLTSSEVVPDVNKLLKS-NTIGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVP 108
            ||.|.|..|.:::::.: ..:...||.|.......::.:||.||.:||||:|:.:.::.:|||||
  Rat   111 KLLSKEPSPPIDEVINTPGVVDRFVEFLKRSENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVP 175

  Fly   109 RLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLMSIIQDKSTCTLMLSHVTWVL 173
            ..|.||.|...:|.|:.:.:|||:...:...|||::...::..|:::: .|||...|..:..|.|
  Rat   176 IFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLL-TKSTRLTMTRNAVWAL 239

  Fly   174 RKLCISSQPSPPDNA--AEIIQALNIVLYNPEANVLEDALMAVRNLAHG-NETIQMLLDFEVVPR 235
            ..||....| ||:.|  :..:..|:.:|::.::::|.||..|:..|:.| ||.||.::|..|..|
  Rat   240 SNLCRGKNP-PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRR 303

  Fly   236 IIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNSDPDIRCQVLKLLLNI 300
            ::.||.|.:..|.:.||:|:.||.||.:.|.|.:||.:.||.|..|:|:|...||.:....:.||
  Rat   304 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNI 368

  Fly   301 ADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFCN 365
            ..||..|..|:::|.:...::|.|:......:..||..||..........:.||:..|.|...|:
  Rat   369 TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCD 433

  Fly   366 LLFCQERDILSNVLDILSTML------------DVDPSFSAEVSGIIEWSGALNNIRMLQSSEHE 418
            ||...:..|:...|:.|..:|            .|:|     ..|:||.:..|:.|..|||.|::
  Rat   434 LLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNP-----YCGLIEEAYGLDKIEFLQSHENQ 493

  Fly   419 EIAAVARKIIGNYF 432
            ||...|..:|.:||
  Rat   494 EIYQKAFDLIEHYF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	36/120 (30%)
		armadillo repeat	98..134	CDD:293788	14/35 (40%)
		armadillo repeat	140..176	CDD:293788	10/35 (29%)
		ARM	189..301	CDD:237987	39/112 (35%)
		armadillo repeat	192..217	CDD:293788	6/24 (25%)
		armadillo repeat	224..260	CDD:293788	14/35 (40%)
		armadillo repeat	266..300	CDD:293788	11/33 (33%)
		ARM	276..385	CDD:237987	30/108 (28%)
		armadillo repeat	308..342	CDD:293788	8/33 (24%)
		armadillo repeat	350..383	CDD:293788	9/32 (28%)
		Arm_3	400..>433	CDD:292804	14/33 (42%)
Kpna6	NP_001015029.2	SRP1	41..530	CDD:227396	126/404 (31%)
		armadillo repeat	131..157	CDD:293788	7/25 (28%)
		armadillo repeat	165..201	CDD:293788	14/35 (40%)
		armadillo repeat	207..242	CDD:293788	10/35 (29%)
		armadillo repeat	259..284	CDD:293788	6/24 (25%)
		armadillo repeat	292..328	CDD:293788	14/35 (40%)
		armadillo repeat	334..368	CDD:293788	11/33 (33%)
		armadillo repeat	376..412	CDD:293788	8/35 (23%)
		armadillo repeat	419..453	CDD:293788	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820