DRSC/TRiP Functional Genomics Resources

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Protein Alignment alphaKap4 and Kpna5

DIOPT Version :10

Sequence 1:NP_648007.1 Gene:alphaKap4 / 38675 FlyBaseID:FBgn0035657 Length:442 Species:Drosophila melanogaster
Sequence 2:NP_001020284.2 Gene:Kpna5 / 294392 RGDID:1561324 Length:539 Species:Rattus norvegicus


Alignment Length:400 Identity:116/400 - (28%)
Similarity:201/400 - (50%) Gaps:15/400 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 KLTSSEVVPDVNKLL-KSNTIGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVP 108
            ||.|.|..|.::::: |...:...|:.|.......::.:||.||.:||||:..|:.::.:.||||
  Rat   109 KLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVP 173

  Fly   109 RLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKLMSIIQDKSTCTLMLSHVTWVL 173
            ..||||.|...:|.|:.:.:|||:.......||:::...::..|:.::.:.:..|...:.| |.|
  Rat   174 IFIRLLTSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAV-WAL 237

  Fly   174 RKLCISSQPSPPDNAAEIIQALNI---VLYNPEANVLEDALMAVRNLAHG-NETIQMLLDFEVVP 234
            ..||...  :||.|.:::...||:   :|::.:.:||.|...|:..|:.| |:.||:::|..|..
  Rat   238 SNLCRGK--NPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQVVIDSGVCR 300

  Fly   235 RIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNSDPDIRCQVLKLLLN 299
            |::.||.|.:..|.:.||:|:.||.||.:.|.|.:||.:.||.|..|:.:....:|.:....:.|
  Rat   301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLGSPKESVRKEACWTISN 365

  Fly   300 IADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFC 364
            |..||..|..|:::..:...::|.|:......:..||..||..........:.||:..|.|...|
  Rat   366 ITAGNRMQIQAVIDGSIFPVLIEVLQKAEFRTRKEAAWAITNATSGGAPEQIRYLVTLGCIKPLC 430

  Fly   365 NLLFCQERDILSNVLDILSTMLDVDPSFSAE-------VSGIIEWSGALNNIRMLQSSEHEEIAA 422
            :||...:..|:...|:.|..:|.:....|.:       ...:||.:..|:.|..|||.|::||..
  Rat   431 DLLTVMDSKIVQVALNGLENILRLGERESKQNGVGINPYCALIEEAYGLDKIEFLQSHENQEIYQ 495

  Fly   423 VARKIIGNYF 432
            .|..:|..||
  Rat   496 KAFDLIERYF 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaKap4NP_648007.1 SRP1 45..432 CDD:227396 114/398 (29%)
armadillo repeat 98..134 CDD:293788 14/35 (40%)
armadillo repeat 140..176 CDD:293788 7/35 (20%)
armadillo repeat 192..217 CDD:293788 7/27 (26%)
armadillo repeat 224..260 CDD:293788 14/35 (40%)
armadillo repeat 266..300 CDD:293788 8/33 (24%)
armadillo repeat 308..342 CDD:293788 7/33 (21%)
armadillo repeat 350..383 CDD:293788 9/32 (28%)
Kpna5NP_001020284.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38
SRP1 36..528 CDD:227396 115/399 (29%)
Nuclear localization signal. /evidence=ECO:0000250 45..54
ARM 1, truncated 76..118 4/8 (50%)
ARM 2 119..162 11/42 (26%)
armadillo repeat 122..155 CDD:293788 7/32 (22%)
NLS binding site (major). /evidence=ECO:0000250 150..242 29/92 (32%)
armadillo repeat 163..199 CDD:293788 14/35 (40%)
armadillo repeat 205..240 CDD:293788 7/35 (20%)
ARM 4 208..246 7/40 (18%)
ARM 5 247..291 12/43 (28%)
armadillo repeat 257..282 CDD:293788 7/24 (29%)
armadillo repeat 290..326 CDD:293788 14/35 (40%)
ARM 6 292..331 14/38 (37%)
NLS binding site (minor). /evidence=ECO:0000250 319..407 25/87 (29%)
armadillo repeat 332..366 CDD:293788 8/33 (24%)
ARM 8 374..413 7/38 (18%)
armadillo repeat 374..410 CDD:293788 7/35 (20%)
ARM 9 414..456 11/41 (27%)
armadillo repeat 417..451 CDD:293788 10/33 (30%)
ARM 10, atypical 460..505 12/44 (27%)
Blue background indicates that the domain is not in the aligned region.

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