DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaKap4 and Spag6

DIOPT Version :9

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001099595.1	Gene:	Spag6 / 291340	RGDID:	1305616	Length:	509	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	68/290 - (23%)
Similarity:	133/290 - (45%)	Gaps:	36/290 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IASGSSEHSNL--IAKAGAVPRLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGLMQKL 152
            :|..::...|:  :..||.:..|..||....|.:.:...|:||.|.::..:|.:.:::..::.:|
  Rat    24 VAEQATRPQNIETLQNAGIMSLLRPLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKGDILPQL 88

  Fly   153 MSIIQDKSTCTLMLSHVTWVLRKLCISSQPSPPDNAAEI----IQALNIVLYNPEANVLEDALMA 213
            :..:.::: |....: ..:|||.:   .:.||....|.:    :.:|.|.|.:.:..|.|.|..|
  Rat    89 VYSLAEQN-CVYKKA-AAFVLRAV---GKHSPQLAQATVDCGALDSLVICLEDFDPGVKEAAAWA 148

  Fly   214 VRNLA-HGNETIQMLLDFEVVPRIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNNLLPH 277
            :..:| |..|..|.::|...||.::..::.|.:.::..|..||.:|:..|.|..|.:::...:.|
  Rat   149 LAYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDISKHSPELAQTVVDVGAIAH 213

  Fly   278 LSALMSNSDPDIRCQVLKLLLNIADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALTITTL 342
            |:.::.|.|..::.|||..|.:||..::.....::.|.:...:|.|||
  Rat   214 LAQMILNPDEKLKQQVLSALSHIAKHSVDLAEMVVEAEIFPVVLTCLK----------------- 261

  Fly   343 AIDKD---KNLLCYLMRQGV--IPEFCNLL 367
              |||   |...|.|:|:..  .||...|:
  Rat   262 --DKDDFVKKNACTLIREIAKHTPELSQLI 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaKap4	NP_648007.1	ARM	57..177	CDD:237987	18/88 (20%)
		armadillo repeat	98..134	CDD:293788	11/37 (30%)
		armadillo repeat	140..176	CDD:293788	5/35 (14%)
		ARM	189..301	CDD:237987	31/116 (27%)
		armadillo repeat	192..217	CDD:293788	7/24 (29%)
		armadillo repeat	224..260	CDD:293788	9/35 (26%)
		armadillo repeat	266..300	CDD:293788	9/33 (27%)
		ARM	276..385	CDD:237987	25/97 (26%)
		armadillo repeat	308..342	CDD:293788	5/33 (15%)
		armadillo repeat	350..383	CDD:293788	6/20 (30%)
		Arm_3	400..>433	CDD:292804
Spag6	NP_001099595.1	armadillo repeat	34..70	CDD:293788	10/35 (29%)
		armadillo repeat	76..108	CDD:293788	3/33 (9%)
		SRP1	112..>423	CDD:227396	50/197 (25%)
		armadillo repeat	127..152	CDD:293788	7/24 (29%)
		armadillo repeat	162..194	CDD:293788	7/31 (23%)
		armadillo repeat	202..238	CDD:293788	10/35 (29%)
		armadillo repeat	244..278	CDD:293788	12/52 (23%)
		armadillo repeat	328..360	CDD:293788
		HEAT repeat	378..406	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900