back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaKap4 and ARMC3

DIOPT Version :10

Sequence 1:	NP_648007.1	Gene:	alphaKap4 / 38675	FlyBaseID:	FBgn0035657	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_775104.2	Gene:	ARMC3 / 219681	HGNCID:	30964	Length:	872	Species:	Homo sapiens

Alignment Length:	532	Identity:	117/532 - (21%)
Similarity:	193/532 - (36%)	Gaps:	146/532 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RFLKKGQNLMMLRTLRLEKAKKAELQKELTIYNALTKCK-------LTSSEVVPDVNKLLKS-NT 63
            :|..||:.   .:|..||......|.|.||..:.:.:..       |.|:.   ||.|||:. :.
Human    51 KFALKGEE---NKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNN---DVKKLLRELDV 109

  Fly    64 IGNLVESLGHGNKNKIRADAADALAHIASGSSEHSNLIAKAGAVPRLIRLLQSPDPEVCEKGILS 128
            :.:::..|....:..|...|:..||::::..:....:....|..| |||||.||||:|.:..:..
Human   110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMEC 173

  Fly   129 LGNL------------LHFAPNLRD-----YIIRHGLMQKLMSII-QDKSTCTLM-----LSHV- 169
            :.||            |:..|.:.|     |.:...|..|.:.:| .||.:.|::     |.|:
Human   174 IYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLI 238

  Fly   170 ----------------------------------TWVLRKLCISSQPSP-PDNAAEIIQALNIVL 199
                                              |..|:||...::.|. ||......:|:....
Human   239 KILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAA 303

  Fly   200 YNPEANVL------EDALMAVRNLAHGNETIQMLL--------------DF---EVVPRIIYLLE 241
            |:||...|      |..|:|:  |...|:..::..              ||   :.:|::|.||:
Human   304 YDPENRKLFHEQEVEKCLVAL--LGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLK 366

  Fly   242 HPNVTVQNAALQALINIATGSEEQIQELLNNNLLPHLSALMSNSDPDIRCQVLKLLLNIADGNIF 306
            ..|..|:.||..||.|:.|.:..........:.:..|..|:|:...........:|.|:|    .
Human   367 SDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMA----M 427

  Fly   307 Q---RHAIMNAGLLHKILECLKADAISLKSAAALTITTLAIDKDKNLLCYLMRQGVIPEFCNLL- 367
            |   |..|.|..::|.|:..|::....::|.|||.:|..|.|.:..  ..|...|.:.....||
Human   428 QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEAR--TELRNSGGLEPLVELLR 490

  Fly   368 ---------------FCQERDILSN------VLDILSTMLDVDPSFSAEVSGI-------IEWSG 404
                           .|...::.:|      .||||.         ...|||.       ..::.
Human   491 SKNDEVRKHASWAVMVCAGDELTANELCRLGALDILE---------EVNVSGTRKNKFSEAAYNK 546

  Fly   405 ALNNIRMLQSSE 416
            .|||...|:.|:
Human   547 LLNNNLSLKYSQ 558

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.