DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myh6 and zip

DIOPT Version :9

Sequence 1:NP_942118.1 Gene:myh6 / 386711 ZFINID:ZDB-GENE-031112-1 Length:1936 Species:Danio rerio
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:1971 Identity:745/1971 - (37%)
Similarity:1178/1971 - (59%) Gaps:98/1971 - (4%)


- Green bases have known domain annotations that are detailed below.


Zfish    38 FVVDEKVEYVKGQIQNKDGGKVTVK-TEDGRTVTVKDGDVHPQNPPKFDKIEDMAMLTFLHEPAV 101
            :|..|...:|...|:.:.|.:|.|: .|.|:.|.:...|:...|||||||:||||.||.|:|.:|
  Fly    83 WVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASV 147

Zfish   102 LFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYDADVVAAYRGKKRTEAPPHIFSISDNAYQYML 166
            |.|:|:||.:.:||||||||||.|||||.||:|...::..|:|.||.|.|||:|:|:|:||:.||
  Fly   148 LHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNML 212

Zfish   167 TDRENQSVLITGESGAGKTVNTKRVIQYFASIAAA--GGS---------------TGK------- 207
            .|||:||:|.|||||||||.|||:|||:.|.:||:  .||               |.|       
  Fly   213 GDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIM 277

Zfish   208 --------------------KDSSKGTLEDQIIQANPALEAFGNAKTLRNDNSSRFGKFIRIHFG 252
                                .:..:|.||.|::||||.|||||||||::|||||||||||||:|.
  Fly   278 AQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 342

Zfish   253 TSGKLSSADIETYLLEKSRVTFQLKSERNYHIFFQILSNEKPELLDMLLITNNPYDYSYISQGEV 317
            .||.:|.|:||||||||||...|.|.||.:|||:|:|:...||..:..:: ::...|:::|.|.:
  Fly   343 ASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSL 406

Zfish   318 TVSSINDNEELIATDKAFDVLGFTSEEKMGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDAD 381
            .|..::|..|..||.|:.:::|.|||:...::::..|::.:|:|||:|::..:||. ||.|. |.
  Fly   407 PVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTV-AQ 470

Zfish   382 KAAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVDQVYYSIGALAKSVYEKMFNWMVVRINQSL 446
            |.|:|:||:..|:.:....||:|||.::|||.|:.:||.:::.|:||:.||:||.|:|.|||:||
  Fly   471 KIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSL 535

Zfish   447 D-TKQHRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFI 510
            | ||:....|||:||:||||||:.|:|||||||:|||||||.|||.||:||||||::|||:|:||
  Fly   536 DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI 600

Zfish   511 DFGMDLQSCIDLIEKPLGIMSILEEECMFPKASDQTFKAKLYDNHLGKTNIFQKPRAVKG--KAE 573
            |||:|||..||||:||.|||::|:|||.||||:|:||..||...|      ...|:.:|.  :..
  Fly   601 DFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMKTDFRGV 659

Zfish   574 AHFALSHYAGTVDYNIAGWLVKNKDPLNETVVGLYQKS----------SLKLLSLLFSSYAGSDG 628
            |.||:.||||.|||:.|.||:||.|||||.:|.|.|.|          ..:::.:...:...:..
  Fly   660 ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQF 724

Zfish   629 GEKSGGKGAKKKGSSFQTVSALHRENLNKLMTNLKTTHPHFVRCLIPNESKIPGIMDNCLVMHQL 693
            |.::      :|| .|:|||.|::|.|.|||..|:.|:|:||||:|||..|..|.:|..||:.||
  Fly   725 GART------RKG-MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQL 782

Zfish   694 RCNGVLEGIRICRKGFPNRILYGDFKQRCRILNASAIPEGQFIENKKSAEKLLGSLDIDHTQYKF 758
            |||||||||||||:||||||.:.:|:||..:|..:.||:| |::.||:.||::.:|::|...|:.
  Fly   783 RCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRV 846

Zfish   759 GHTKVFFKAGLLGTLEEMRDDQLARILTGIQAFARGLLMRVEYQKLVERRDALMVVQWNLRSFLG 823
            |.:|:||:||:|..|||.||.:::.::...|||.||.|.|..|||.:::.:|:.::|.|..::|.
  Fly   847 GQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLK 911

Zfish   824 VKNWPWMKLFFKIKPLLKSAESEKEMANMKDEFNKLKEALEKSDARRKELEEKMVSLLQEKNDLL 888
            ::||.|.:|:.|:||||:..:.|:::...:||..:::|.|:......:|.|.|....|.||..|.
  Fly   912 LRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLA 976

Zfish   889 LQVQSEQDTLTDAEERCEQLIKSKIQLEAKVKELSERIEDEEEINADLTAKRRKLEDECSELKKD 953
            .|:|:|.:...:|||...:|:..|.:||..::||..|||:|||....|..:::|||....:|::.
  Fly   977 EQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQ 1041

Zfish   954 IDDLELTLAKVEKEKHATENKVKNITEEMASLDENIMKLTKEKKALQEAHQQTLDDLQSEEDKVN 1018
            :::.|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|..
  Fly  1042 LEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAK 1106

Zfish  1019 TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERSKRKLEGDVKLTQENVMDLENDKQQLEDKLKKK 1083
            .|.|.|.|.|..:.:||..|.::::.|.:.:|||||:|.:|...:|.:.:......:::.:|.|:
  Fly  1107 HLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKR 1171

Zfish  1084 DFEINQLNQRIEDEQMASVQLQKKLKENQARIEELEEELDAERAARAKVEKQRSDISRELEDISE 1148
            :.|:.|...||::|.......||..:|.::::.|::|:|:||:|||||.||.|.|:|.|||.:..
  Fly  1172 EEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKN 1236

Zfish  1149 RLEEAGGATSAQVELNKKRDAEFQKIRRDLEESTLQHEATTASLRKKHADSVAELGEQIDNLQRV 1213
            .|.::...|:||.||..||:.|...:::.|||.|:.||...|.:|.||:..:..:.:|::||::.
  Fly  1237 ELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKA 1301

Zfish  1214 KQKLEKEKVELKLELDDLASNMESIVKAKVNLEKMCRSLEDQMNEHRSKAEEAQRALNDVSTQKA 1278
            |..|||.|..|:.|..|||:.:.|:..::...::..:..|.|:.|.:.|..|.:||.:::..:..
  Fly  1302 KTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCT 1366

Zfish  1279 KLLTENGELGRQLEEKECLISQLTRGKTSYAQQLEDLRRQLEEEVKAKNALAHAVQSARHDCDLL 1343
            ||..|...:..||||.|...|...:..::...||.:.::.||||.:.|..|:..::....:.:.|
  Fly  1367 KLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEAL 1431

Zfish  1344 REQFEEEQEAKAELQRALSKANTEVATWRARYETDGIQRTEELEDAKKKLVQKLQDAEEAVEAVN 1408
            :||.||:.|||...:|.|::..|::...:.:.|.|. ...:|||:.||:|.:.::..|..|:.:.
  Fly  1432 QEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELI 1495

Zfish  1409 AKCSSLEKTKHRLQNEIEDLMLDLERSNAASAALDKKQRSFDKVMAEWKQKYEESQCELEGAQKE 1473
            |:...|:|:|.::|:|:||..::||........|:|||::|||::||.|...|:...|.:.|::|
  Fly  1496 AQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAERE 1560

Zfish  1474 ARSLSTELFKLKNSYEETLDHLETIKRENKNLQEEISDLTDQVSEGRKSVHELEKLRKQLEQEKT 1538
            ||...|::..:....:|..|.:|.::.:.|.||.|:.||.:......|:||||||.::.||.:..
  Fly  1561 AREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLA 1625

Zfish  1539 ELQSALEEADASVEHEEGKILRAQLEFNQLKADFERKMSEKDEEMEQARRNYQRMIESLQASLEA 1603
            ||::..||.:..::..|...||.::....|::.|||.:..|:|..|:.||...:.:..|:..|:.
  Fly  1626 ELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDE 1690

Zfish  1604 ETRSRNEALRVKKKMEGDLNEMEIQLSQANRQAADAQKQLKMVQSCLKETQLQMDDTLHSNDDLK 1668
            |.:.|..|:..|||:||||.|:|..:...|:...||.|..|.:|:.:|:.....::...:.::|:
  Fly  1691 ERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQ 1755

Zfish  1669 ENITLLERRNNLMQTELEELRGILEQTERVRKLAEQELTDATERMQLLHSQNTG--LINQKKKQE 1731
            ......||:...::.|:.:|...|..:||.|:.||.|..:..|  ::.::.|.|  :|::|::.|
  Fly  1756 ALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE--EIANNANKGSLMIDEKRRLE 1818

Zfish  1732 SDLLQLQNELEELVQENRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
            :.:..|:.||||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|
  Fly  1819 ARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKEL 1880

Zfish  1794 QHRLDEAEQVAMKGGKKQLQKMEARIRELENELDAEQKRGSESVKGVRKFERRIKELTYQTDEDR 1858
            :.:|.|.|.......|..:..:||:|..||.:|:.|.|......|..||.:::|||||...:::|
  Fly  1881 KAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDER 1945

Zfish  1859 KNLARLQDLVDKLQLKVKSYKRSAEEAEELANANTAKLRKLQHELEEAEERADIAESQVNKLRAK 1923
            :::.:.::.:|||..::|..||:.:|.||.......:.||.|.|.|:..|..:....::|.|:.|
  Fly  1946 RHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTK 2010

Zfish  1924 TR------------DGAPGKK 1932
            .|            .|.|..|
  Fly  2011 LRRTGGIGLSSSRLTGTPSSK 2031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myh6NP_942118.1 Myosin_N 35..72 CDD:280832 10/34 (29%)
Myosin_head 87..766 CDD:278492 355/736 (48%)
MYSc_class_II 99..766 CDD:276951 347/724 (48%)
Myosin_tail_1 846..1923 CDD:279860 335/1081 (31%)
RILP-like 961..1094 CDD:304877 41/132 (31%)
BAR 1298..1490 CDD:299863 57/191 (30%)
MreC 1493..>1578 CDD:302802 28/84 (33%)
TMPIT 1738..>1833 CDD:285135 29/97 (30%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/33 (30%)
Myosin_head 133..854 CDD:278492 355/736 (48%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 347/724 (48%)
Myosin_tail_1 931..2011 CDD:279860 335/1085 (31%)
Prefoldin 1431..1515 CDD:298833 28/84 (33%)
FAM76 <1847..1926 CDD:292665 20/78 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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