DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and RCCD1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001017919.1	Gene:	RCCD1 / 91433	HGNCID:	30457	Length:	376	Species:	Homo sapiens

Alignment Length:	185	Identity:	56/185 - (30%)
Similarity:	81/185 - (43%)	Gaps:	48/185 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PKAKRARIAFHLELPKRRTVL----GNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDI 79
            |.|...| |..|||.....:|    |.|...|.|..||||.|  |..||.:.|..:.|:..| ::
Human   153 PLAPELR-ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMA-EV 215

  Fly    80 SAGGMHNLVLTKSGDIYSFGCNDEGALGRDT-----------------SEDGSESK--------- 118
            :|||.|::.::::||||.:|.|:.|.|...|                 :||||:.|
Human   216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280

  Fly   119 ----------PDLIDLP--GKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMG 161
                      |.|:|||  ..|:..|.|..|:|.:...|.::.||  ...:|.:|
Human   281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWG--WGKYGQLG 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	19/48 (40%)
		RCC1	92..141	CDD:278826	24/86 (28%)
		RCC1_2	131..158	CDD:290274	7/26 (27%)
		RCC1	144..193	CDD:278826	5/18 (28%)
		RCC1_2	182..209	CDD:290274
		RCC1	363..414	CDD:278826
RCCD1	NP_001017919.1	Interaction with KDM8. /evidence=ECO:0000269\|PubMed:24981860	1..169		7/16 (44%)
		ATS1	<156..340	CDD:227511	54/182 (30%)
		RCC1 2	176..227		19/51 (37%)
		RCC1 3	229..317		24/87 (28%)
		RCC1 4	318..371		5/18 (28%)
		RCC1	319..366	CDD:395335	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840