Protein Alignment Rcc1 and EEA1

DIOPT Version :9

• Sequence 1: NP_523943.1
• Gene: Rcc1 / 38669
• FlyBaseID: FBgn0002638
• Length: 547
• Species: Drosophila melanogaster
• Sequence 2: XP_011537116.1
• Gene: EEA1 / 8411
• HGNCID: 3185
• Length: 1453
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 102/494 - (20%)
• Similarity: 177/494 - (35%)
• Gaps: 161/494 - (32%)

  Fly   145 GRVFAWGSFRDSHGNMGLTIDGN--------------KR--TPIDLME----------------- 176
            |||.:.||..||......|:|.|              ||  |.|||:|
Human    11 GRVGSQGSDLDSSATPINTVDVNNESSSEGFICPLCMKRCITAIDLLEHYQKVHDENETRGQELL 75

  Fly   177 ------GTVC--CSIASG-AD----HLVILTTAGKVFTVGCAEQGQLGRLS-------------- 214
                  |.:|  |..:.| ||    |...:..||.       :.|..|..:
Human    76 NDSSVTGFICPQCMKSLGSADELFKHYEAVHDAGN-------DSGHGGESNLALKRDDVTLLRQE 133

  Fly   215 ----ERSISGE---GRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLN-NF 271
                :.|:..|   ....|::|.:...|....|||...:  |:....::..:.|:..|...| |.
Human   134 VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV--TDSSAELQSLEQQLEEAQTENFNI 196

  Fly   272 KQL--AHETKGKEFA--LTPIKTELKDIRHIAGGQHHTVILTT-----------DLKCSVVGRPE 321
            ||:  ..|.|..:.|  :..||::..:.|.:.......|...|           |||..::.||
Human   197 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP- 260

  Fly   322 YGRLGLGDV----KDVVEKPTIVKKLT-------EKIVSVGCGEVCSYAVTIDGKLYSWGSGVNN 375
                |:.||    |::|:..|::..:|       ||:.. .|.::.|.        |:......:
Human   261 ----GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD-ECKKLQSQ--------YASSEATIS 312

  Fly   376 QLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSISKKD 440
            ||                      ...||.|..:.|:::.:..|.....|         .:::|:
Human   313 QL----------------------RSELAKGPQEVAVYVQELQKLKSSVN---------ELTQKN 346

  Fly   441 KTPPQDNVDKEAENVDKQEQKENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKAST 505
            :| ..:|:.|:.::..|.|:|.|    ..:.||||     ..|....:::|.|:.:..|.| :.|
Human   347 QT-LTENLLKKEQDYTKLEEKHN----EESVSKKN-----IQATLHQKDLDCQQLQSRLSA-SET 400

  Fly   506 SSKKI--KTPPQDDAAEEVEEESAQEPTPKKAKKPAAKR 542
            |..:|  :...:.:|.::::||.::..|..:..|...|:
Human   401 SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826
		RCC1	92..141	CDD:278826
		RCC1_2	131..158	CDD:290274	7/12 (58%)
		RCC1	144..193	CDD:278826	24/93 (26%)
		RCC1_2	182..209	CDD:290274	6/31 (19%)
		RCC1	363..414	CDD:278826	7/50 (14%)
EEA1	XP_011537116.1	Myosin_tail_1	308..1382	CDD:279860	34/174 (20%)
		DUF342	<425..519	CDD:302792	3/15 (20%)
		FYVE_EEA1	1389..1451	CDD:277269

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900