DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and Als2

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001153420.2	Gene:	Als2 / 74018	MGIID:	1921268	Length:	1651	Species:	Mus musculus

Alignment Length:	649	Identity:	130/649 - (20%)
Similarity:	209/649 - (32%)	Gaps:	267/649 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PKR------RTVL-------GNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDA-------VDI 79
            |:|      :|||       ..||:..:|:|...|......|...:.|.:.:.::       :.:
Mouse    32 PERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEICPSSPLLESALVGHHVITV 96

  Fly    80 SAGGMHNLVLTKSGDIYSFGCNDEGALGR-------------DTSEDGSESKPDLIDLPGKALCI 131
            :.|..|:..:|:||.:|.:|   |.|.|:             ..|...||:.|   .|..:.|.:
Mouse    97 ATGSFHSGAVTESGVVYMWG---ENAAGQCAVANQQYVPEPSPVSISDSETSP---SLAVRILQL 155

  Fly   132 SAGDSHSACLLEDGRVFAWGSFRDSHG-NMGL---TIDGNKRTPIDLMEGTVCCSIASGA----- 187
            :.|:.|:..|.....::|||:     | .:||   |....|...::.:.|.|...:|.||
Mouse   156 ACGEEHTLALSLSREIWAWGT-----GCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215

  Fly   188 -------------------------------DHLVI----------------------------- 192
                                           ||::|
Mouse   216 LVQCLPPQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLSESQAEKHASPAPSPHP 280

  Fly   193 --LTTAGKVF---------------------------TVGCAE----------------QGQLGR 212
              |...|:||                           .||.||                ...|.:
Mouse   281 EALDEQGEVFENTVVEAELNMGSSQTTSGSAISTQQNVVGTAEVSSARTAPSYPDTHAVTAYLQK 345

  Fly   213 LSERSISGEGRRGKR-------------DLLRP--------TQLIITRAK--------PFEA--- 245
            |||.|:......|::             ||..|        ..|:::.|.        .:||
Mouse   346 LSEHSMRENHEPGEKPPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGAL 410

  Fly   246 -------IWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIR--HIAGG 301
                   .::|..|....:|.:.   :||..:.|.|..|...:|.......:.|.|||  .:.||
Mouse   411 SLKKVMNFYSTAPCETAAQSGSA---STGPESLKDLREEQVKQESLQGKKSSSLMDIREEELEGG 472

  Fly   302 QH------------------------HTVILT-----------TDLKCSV--VGRPEYGRLGLGD 329
            ..                        .||:||           ..|:..|  .|:.:.|:||.||
Mouse   473 SRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGD 537

  Fly   330 VKDVVEKPTIVKKLTEK-IVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVV-- 391
            |...:: |..||.|..| ::.:..|...|.|:|...::|||||....|||..:     .|..|
Mouse   538 VLPRLQ-PLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSE-----FPTTVPR 596

  Fly   392 VSKNTQGKHMLLASGGGQHAIFLVKAD----------KQDQKE--NVPVKVSGSSSISKKDKTP 443
            :||.:....:...:.|..:::|||..:          :||:.|  .:|...||:       |||
Mouse   597 LSKVSSENGVWSVAAGQDYSLFLVDTEDFQPGLYYSGRQDRAEGDTLPENPSGT-------KTP 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	9/53 (17%)
		RCC1	92..141	CDD:278826	15/61 (25%)
		RCC1_2	131..158	CDD:290274	6/26 (23%)
		RCC1	144..193	CDD:278826	16/119 (13%)
		RCC1_2	182..209	CDD:290274	14/136 (10%)
		RCC1	363..414	CDD:278826	13/52 (25%)
Als2	NP_001153420.2	RCC1 1. /evidence=ECO:0000305	59..108		7/48 (15%)
		RCC1_2	93..122	CDD:290274	9/31 (29%)
		RCC1 2. /evidence=ECO:0000305	109..167		16/63 (25%)
		RCC1	109..165	CDD:278826	15/61 (25%)
		RCC1 3. /evidence=ECO:0000305	169..218		13/53 (25%)
		RCC1	170..216	CDD:278826	13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..462		7/39 (18%)
		RCC1 4. /evidence=ECO:0000305	519..570		16/51 (31%)
		RCC1	521..568	CDD:278826	15/47 (32%)
		RCC1 5. /evidence=ECO:0000305	572..621		15/53 (28%)
		RCC1	573..619	CDD:278826	13/50 (26%)
		RhoGEF	689..873	CDD:295373
		PH_alsin	899..1004	CDD:241423
		PH	920..998	CDD:278594
		COG4642	1043..1182	CDD:226989
		MORN 1	1043..1065
		MORN	1043..1063	CDD:280628
		MORN 2	1066..1088
		MORN 3	1094..1116
		MORN	1094..1114	CDD:280628
		MORN 4	1117..1139
		MORN 5	1145..1167
		COG4642	1166..>1266	CDD:226989
		MORN 6	1169..1191
		MORN 7	1192..1214
		MORN 8	1215..1238
		VPS9	1548..1647	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830