DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and Rcc1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_006239135.1	Gene:	Rcc1 / 682908	RGDID:	1592835	Length:	434	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	181/430 - (42%)
Similarity:	252/430 - (58%)	Gaps:	22/430 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERKR 66
            |...|:..:....:...:.|..:..:::..    ...|..|.||..|.||||||||||.:||||:
  Rat    12 PPEDAIPKSKKVKDTRNRRPAPRSCQVSHR----SHNTEPGLVLTLGQGDVGQLGLGESVLERKK 72

  Fly    67 LSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCI 131
            .:.|..:.|.|...|||||.:.|::||.:||||||||||||||||.:|||..|..::|..|.:.:
  Rat    73 PALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQV 137

  Fly   132 SAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRT--PIDLMEGTVCCSIASGADHLVILT 194
            ||||||:|.|.||||||.||||||::|.:|| ::..|::  |:.:...|....:|||.||||:||
  Rat   138 SAGDSHTAALTEDGRVFLWGSFRDNNGVIGL-LEPMKKSMVPVQVQLDTQVVKVASGNDHLVMLT 201

  Fly   195 TAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLII----TRAK-PFEAIWATNYCTF 254
            |.|.::|:||.|||||||:.|...:..||:|...||.|..:::    ||.: .|:..:...|.||
  Rat   202 TDGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTF 266

  Fly   255 --MRESQTQVIWATGLNNFKQLAHETKGKEFA---LTPIKTELKDIRHIAGGQHHTVILTTDLKC 314
              .||..   ::..||:|:.||.....|..|.   ||..|...|.....:|||||||.:.::.|.
  Rat   267 AISREGH---VYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKA 328

  Fly   315 SVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGV 379
            ..:||.||||||||:..:....||::.:| ..:.||.||....|||:.||::::||.|.|.|||.
  Rat   329 YSLGRAEYGRLGLGEGAEEKSIPTLISRL-PVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGT 392

  Fly   380 GDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADK 419
            |..||...|:.:..|..:.:.:|..|.||||.:.||| ||
  Rat   393 GQEDDAWSPVEMTGKQLENREVLTVSSGGQHTVLLVK-DK 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	26/46 (57%)
		RCC1	92..141	CDD:278826	31/48 (65%)
		RCC1_2	131..158	CDD:290274	20/26 (77%)
		RCC1	144..193	CDD:278826	24/50 (48%)
		RCC1_2	182..209	CDD:290274	16/26 (62%)
		RCC1	363..414	CDD:278826	20/50 (40%)
Rcc1	XP_006239135.1	ATS1	19..432	CDD:227511	179/423 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55567
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2471
OMA	1	1.010	-	-		QHG58672
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0004765
OrthoInspector	1	1.000	-	-		oto97564
orthoMCL	1	0.900	-	-		OOG6_100545
Panther	1	1.100	-	-	LDO	PTHR45982
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2826
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810