DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and RPGR

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001030025.1	Gene:	RPGR / 6103	HGNCID:	10295	Length:	1152	Species:	Homo sapiens

Alignment Length:	679	Identity:	153/679 - (22%)
Similarity:	244/679 - (35%)	Gaps:	199/679 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRRKALTNNNNAGEAEQQPPKA-KRARIAFHLELPKRRT--VLGN--VLVCGNGDVGQLGLGED 60
            ||...|:.....:..||..|.|. .:..:..||......:  |.||  :.:.|:.:.||||||..
Human     8 MPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK 72

  Fly    61 ILERKRLSPVAGIPDAVDISA-GGMHNLVLTKSGDIYSFGCNDEGALG-RDTSEDGSESKPDLID 123
            ....|.....|..|:.|.::| |..|.||.|:.|::|:.|.|:||.|| .||.|..:........
Human    73 SAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFT 137

  Fly   124 LPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGAD 188
            ...|...:|||.:.||.|.||||:|.||.  :|.|.:||....|...|..:..|.....|:.|..
Human   138 SEHKIKQLSAGSNTSAALTEDGRLFMWGD--NSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200

  Fly   189 HLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCT 253
            |...:||.|:::..|..|.|:||                   .|.||:
Human   201 HSAFVTTDGELYVFGEPENGKLG-------------------LPNQLL----------------- 229

  Fly   254 FMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVG 318
                         |.:...||..|...|             :..:|.|..|||:||.: .....|
Human   230 -------------GNHRTPQLVSEIPEK-------------VIQVACGGEHTVVLTEN-AVYTFG 267

  Fly   319 RPEYGRLGLGDVKDVVEKPTIVKKLTEKIVS-VGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDG 382
            ..::|:||||.......:|.:::.:.::.:| :.|||..:..:|..|.:|::|.|.:.:||:|..
Human   268 LGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLE 332

  Fly   383 DDELEPIVVVSKNTQGKHMLLASGGGQH---------------------------AIFLVKAD-- 418
            :.....|..:..|.....:.|.:.||.|                           |.||..:.
Human   333 NFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLT 397

  Fly   419 -------------KQDQKENVPVKVS--------------------------------GSSSISK 438
                         ::.::|..|...|                                ..|.:|:
Human   398 SGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSE 462

  Fly   439 KDKTPPQ------DNVDKEAENVDKQEQKENL--------------------PAKASTSSKKNKT 477
            :|...|:      |.:.|||| :|.....|:|                    ..|.|...|:.|.
Human   463 QDLMQPEEPDYLLDEMTKEAE-IDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQ 526

  Fly   478 P-----PQDNADKEAENVDKQEQ----KENLPAK------------AST----SSKKIKTPPQDD 517
            .     .||.|..|.::.|:.|:    ||....|            |:|    |.::::.|.:.:
Human   527 QTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKE 591

  Fly   518 AAEEVEEESAQEPTPKKAKKPAAKRGGKK 546
            .||:.:....:|...:..::.....||:|
Human   592 GAEDSKGNGIEEQEVEANEENVKVHGGRK 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	17/49 (35%)
		RCC1	92..141	CDD:278826	17/49 (35%)
		RCC1_2	131..158	CDD:290274	14/26 (54%)
		RCC1	144..193	CDD:278826	16/48 (33%)
		RCC1_2	182..209	CDD:290274	8/26 (31%)
		RCC1	363..414	CDD:278826	14/77 (18%)
RPGR	NP_001030025.1	RCC1	<38..312	CDD:332518	91/338 (27%)
RPGR	NP_001030025.1	RCC1	314..360	CDD:306840	12/45 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850