DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and ALS2

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_065970.2	Gene:	ALS2 / 57679	HGNCID:	443	Length:	1657	Species:	Homo sapiens

Alignment Length:	651	Identity:	123/651 - (18%)
Similarity:	206/651 - (31%)	Gaps:	265/651 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PKR------RTVL-------GNVLVCGNGDVGQLGL------------GEDILERKRLSPVAGIP 74
            |:|      :|||       ..||:..:|:|...|.            ...|||...:...
Human    32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQY---- 92

  Fly    75 DAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKP-DLID------LPGKALCIS 132
             .:.::.|..|:..:|.:|..|.:|.|..|.......:...|..| .:.|      |..:.|.::
Human    93 -VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156

  Fly   133 AGDSHSACLLEDGRVFAWGSFRDSHG-NMGLTIDG---NKRTPIDLMEGTVCCSIASGA------ 187
            .|:.|:..|.....::|||:     | .:||....   .|...::.:.|.|...:|.||
Human   157 CGEEHTLALSISREIWAWGT-----GCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 216

  Fly   188 ------------------------------DHLVILTT----AGKVFTVGCAE------------ 206
                                          ||::|..:    .|...|...||
Human   217 VQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTE 281

  Fly   207 ----------------------------------------QGQLG-------------------- 211
                                                    |..:|
Human   282 TLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVN 346

  Fly   212 ----RLSERSISGEGRRGKRDLLRPTQLIITRAKP------------------------------ 242
                :||:.|:..:...|::.:  |:|.::..|.|
Human   347 EYLRKLSDHSVREDSEHGEKPV--PSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAA 409

  Fly   243 -FEA----------IWATNYCTFMRESQTQVIWATGLNNFK--QLAHET-KGKE-FALTPIKTEL 292
             :||          .::|..|....::.:..|...||.:.:  |:..|: :||: .:|..|:.|.
Human   410 TYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEE 474

  Fly   293 KD-------------------IRHIAGGQHHTVILT-----------TDLKCSV--VGRPEYGRL 325
            .:                   :|..|..:..||:||           ..|:..|  .|:.:.|:|
Human   475 TEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQL 539

  Fly   326 GLGDVKDVVEKPTIVKKLTEK-IVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPI 389
            |.|||...:: |..||.|..| ::.:..|...|.|:|...::|||||....|||..|....:..:
Human   540 GHGDVLPRLQ-PLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRL 603

  Fly   390 VVVSKNTQGKHMLLASGGGQHAIFLVKAD----------KQDQKE--NVPVKVSGSSSISKKDKT 442
            ..:| :..|...:.|  |..:::|||..:          :||..|  |:|...|||       ||
Human   604 AKIS-SENGVWSIAA--GRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGS-------KT 658

  Fly   443 P 443
            |
Human   659 P 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	10/58 (17%)
		RCC1	92..141	CDD:278826	12/55 (22%)
		RCC1_2	131..158	CDD:290274	6/26 (23%)
		RCC1	144..193	CDD:278826	14/88 (16%)
		RCC1_2	182..209	CDD:290274	11/118 (9%)
		RCC1	363..414	CDD:278826	13/50 (26%)
ALS2	NP_065970.2	RCC1 1. /evidence=ECO:0000305	59..108		8/53 (15%)
		RCC1_2	93..122	CDD:290274	7/28 (25%)
		RCC1 2. /evidence=ECO:0000305	109..167		13/57 (23%)
		RCC1	109..165	CDD:278826	12/55 (22%)
		RCC1 3. /evidence=ECO:0000305	169..218		12/53 (23%)
		RCC1	170..216	CDD:278826	12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..480		10/47 (21%)
		RCC1 4. /evidence=ECO:0000305	525..576		16/51 (31%)
		RCC1	527..574	CDD:278826	15/47 (32%)
		RCC1 5. /evidence=ECO:0000305	578..627		15/51 (29%)
		RCC1	579..625	CDD:278826	13/48 (27%)
		RhoGEF	695..879	CDD:295373
		PH_alsin	905..1010	CDD:241423
		PH	926..1004	CDD:278594
		COG4642	1049..1188	CDD:226989
		MORN 1	1049..1071
		MORN	1049..1069	CDD:280628
		MORN 2	1072..1094
		MORN 3	1100..1122
		MORN	1100..1120	CDD:280628
		MORN 4	1123..1145
		MORN 5	1151..1173
		MORN 6	1175..1197
		MORN 7	1198..1220
		MORN 8	1221..1244
		VPS9	1554..1653	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830