DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and herc4

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	423	Identity:	117/423 - (27%)
Similarity:	181/423 - (42%)	Gaps:	53/423 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VLVCGNGDVGQLGLG----EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEG 104
            :|..||...||||||    |.:||.:|.....| ....|:..|..|.:.|.:.|.:|:.||||.|
Zfish     1 MLCWGNASFGQLGLGGIDEEVLLEPRRCEFFEG-KRVRDVGCGRRHTVFLLEDGTVYTCGCNDLG 64

  Fly   105 ALGRDTSEDGSESKPD-LIDLPGK-ALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGN 167
            .||.:.    :..||: ::.|..: .:.:|.|::|:..|.:.|:|||||  ..|.|.:||:|..:
Zfish    65 QLGHEK----ARKKPEQVVSLDAQNIVAVSCGEAHTLALNDKGQVFAWG--LGSDGQLGLSIVED 123

  Fly   168 ----KRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRD 228
                .||...|.|..: ..:|.|..|.:.|...|::|:.|..:.||||.         |::| ..
Zfish   124 CLRVPRTVKSLSEVHI-TQVACGYWHSLALARGGEIFSWGQNKYGQLGL---------GQQG-AC 177

  Fly   229 LLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLA-HETKGKEFALTPIKTEL 292
            :..|..:...:..||..|.|....:| ..:.:..|:..|.|.|.||. .:...:.|.:.......
Zfish   178 VCSPQVIQSLQGIPFGQISAGGAHSF-GLTLSGAIFGWGRNKFGQLGLGDNDDRRFPVLLKTLRS 241

  Fly   293 KDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVS-VGCGEVC 356
            :.:.:|..|:.||..||.:......|...||:||.......| .|..|.:|...:|| :.||...
Zfish   242 QQVVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTNHEV-NPRKVFELMGSVVSQIACGRQH 305

  Fly   357 SYA-VTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQ 420
            :.| :...||:.|:|.|.|.|||.....:.:.|..|             .|..:.....|..|..
Zfish   306 TLAFIPSSGKIDSFGLGGNGQLGTRSTCNRISPTPV-------------KGCWRAHADPVAMDHS 357

  Fly   421 DQKENVPVK---VSGSSSIS----KKDKTPPQD 446
            :.:.:..||   ..|..|.:    .:|..||.|
Zfish   358 EAERSYCVKRIYAGGDQSFAHYALSEDDGPPLD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	17/48 (35%)
		RCC1	92..141	CDD:278826	15/50 (30%)
		RCC1_2	131..158	CDD:290274	11/26 (42%)
		RCC1	144..193	CDD:278826	18/52 (35%)
		RCC1_2	182..209	CDD:290274	7/26 (27%)
		RCC1	363..414	CDD:278826	12/50 (24%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826	16/46 (35%)
		RCC1	52..99	CDD:278826	15/50 (30%)
		RCC1	102..152	CDD:278826	18/52 (35%)
		RCC1	156..205	CDD:278826	15/59 (25%)
		RCC1	208..257	CDD:278826	11/48 (23%)
		RCC1	260..308	CDD:278826	13/48 (27%)
		RCC1	313..377	CDD:278826	18/76 (24%)
		HECTc	704..1049	CDD:238033
		HECTc	730..1049	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920