DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and rcc1l

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001076272.1	Gene:	rcc1l / 555972	ZFINID:	ZDB-GENE-060526-370	Length:	451	Species:	Danio rerio

Alignment Length:	426	Identity:	100/426 - (23%)
Similarity:	151/426 - (35%)	Gaps:	132/426 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CGNG---------DVGQL---GLGED------------------ILERKRLSPVA---------G 72
            ||.|         |:.:|   ||.:|                  :||   .|||:         .
Zfish   101 CGYGFTLLASNTKDLTKLWGMGLNKDSQLGFQRTQHDKSKSYDYVLE---ASPVSLPLLNPQETR 162

  Fly    73 IPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSED----GSESKPDLIDLPGKALCISA 133
            :|   .:|.|..|:||||.|..::|.|.|..|..||...||    ||.....:.....:.:.::.
Zfish   163 VP---QVSCGRAHSLVLTDSEGVFSMGSNTFGQCGRKIVEDEVYSGSHVVHKIEGFDSRVIQVAC 224

  Fly   134 GDSHSACLLEDGRVFA--WGSFRDSHGNMGLTIDGNKRTPIDL---MEGTVCCSIASGADHLVIL 193
            |..||..|.:.|.|||  ||    :.|..||........|:.:   :.|.....:|:..|..:.:
Zfish   225 GQDHSLFLTDRGSVFACGWG----ADGQTGLGHHNKASCPVPVGGDLAGVTVQQVATYGDCSLAV 285

  Fly   194 TTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPF-------EAIWATNY 251
            :|.|:||..|.:|..||..::|                .||:...|..|.       :|......
Zfish   286 STDGQVFGWGNSEYLQLASVTE----------------STQISSPRLLPLKGVGRIRQAACGGTQ 334

  Fly   252 CTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSV 316
            ...:.|.....:|..|:..        ||.:.:.:.|...                    :..:.
Zfish   335 VAVLNEDGDVFVWGFGILG--------KGPKLSESAIPER--------------------VPATF 371

  Fly   317 VGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGD 381
            .||.|:             .||:      |:.|:.||.....|||..|:|:.||..|...||:|.
Zfish   372 FGRSEF-------------NPTV------KVASIRCGLSHFAAVTDGGELFVWGKNVRGCLGIGK 417

  Fly   382 GDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKA 417
            .||:..|..|    |...|:...:.|..|.:.|||:
Zfish   418 HDDQYFPWRV----TVPGHVTDVACGVDHMVALVKS 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	18/80 (23%)
		RCC1	92..141	CDD:278826	14/52 (27%)
		RCC1_2	131..158	CDD:290274	10/28 (36%)
		RCC1	144..193	CDD:278826	13/53 (25%)
		RCC1_2	182..209	CDD:290274	8/26 (31%)
		RCC1	363..414	CDD:278826	16/50 (32%)
rcc1l	NP_001076272.1	RCC1	52..108	CDD:278826	3/6 (50%)
		RCC1_2	165..192	CDD:290274	11/26 (42%)
		RCC1	182..232	CDD:278826	13/49 (27%)
		RCC1_2	219..248	CDD:290274	10/32 (31%)
		RCC1	236..285	CDD:278826	13/52 (25%)
		RCC1	288..338	CDD:278826	13/65 (20%)
		RCC1_2	383..412	CDD:290274	11/28 (39%)
		RCC1	400..446	CDD:278826	16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910