DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and rcc1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001016101.1	Gene:	rcc1 / 548855	XenbaseID:	XB-GENE-979094	Length:	420	Species:	Xenopus tropicalis

Alignment Length:	388	Identity:	179/388 - (46%)
Similarity:	243/388 - (62%)	Gaps:	14/388 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TVLGNVLVCGNGDVGQLGLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDE 103
            ||.|.||..|.|||||||||||::|||:.:.|....|.|..:|||||.:.|..||.||:||||||
Frog    34 TVGGQVLTLGQGDVGQLGLGEDVMERKKPALVTLPEDIVQAAAGGMHTVCLGASGSIYTFGCNDE 98

  Fly   104 GALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNK 168
            |||||||||:|||::|..:||..|.:.:||||||:|.|.||||||.:|||||::|.:|| ::..|
Frog    99 GALGRDTSEEGSETQPGKVDLVEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGL-LEPMK 162

  Fly   169 RT--PIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLR 231
            ::  |:.:........||||.||||:||..|.::|.||.|||||||:.||..:..||:|...||.
Frog   163 KSMVPVQMQINAPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRKGLERLLV 227

  Fly   232 PTQLIITRAK-----PFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFA---LTPI 288
            | |.|..:||     .|:.::...|.|| ..||...::..||:|:.||..:|....||   ||..
Frog   228 P-QCIHLKAKGSGRVHFQDVFCGAYFTF-AVSQEGHVYGFGLSNYHQLGTKTTQSCFAPQNLTSF 290

  Fly   289 KTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCG 353
            |...|.....:||||||:.:.::.|...:||.||||||||:..:.:.:||.: .:..|..||.||
Frog   291 KNSTKSWVGFSGGQHHTICVDSEGKVYSLGRAEYGRLGLGENAEELSEPTPI-PILPKTKSVACG 354

  Fly   354 EVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVK 416
            ...||||:.||::::||.|.|.|||.|:.:|...|..:..|..:.:.:|..|.||||.:.||:
Frog   355 ASVSYAVSNDGRVFAWGMGTNLQLGTGEEEDVWSPQEMTGKQLEDRDVLSVSSGGQHTVLLVR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	26/46 (57%)
		RCC1	92..141	CDD:278826	33/48 (69%)
		RCC1_2	131..158	CDD:290274	19/26 (73%)
		RCC1	144..193	CDD:278826	23/50 (46%)
		RCC1_2	182..209	CDD:290274	16/26 (62%)
		RCC1	363..414	CDD:278826	19/50 (38%)
rcc1	NP_001016101.1	ATS1	21..418	CDD:227511	179/388 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55567
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2519
OMA	1	1.010	-	-		QHG58672
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0004765
OrthoInspector	1	1.000	-	-		oto104260
Panther	1	1.100	-	-	LDO	PTHR45982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1072
SonicParanoid	1	1.000	-	-		X2826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110