DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and nek8

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_012812229.1	Gene:	nek8 / 448753	XenbaseID:	XB-GENE-990378	Length:	698	Species:	Xenopus tropicalis

Alignment Length:	364	Identity:	86/364 - (23%)
Similarity:	152/364 - (41%)	Gaps:	77/364 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLID----------LPGKA- 128
            :.|.:|||......:||||.:..:.....|.        |:.|.|..|:          |.|::
Frog   341 EVVQVSAGRTQKAGVTKSGRLIMWEATPVGT--------GAPSLPGSIEHAQPQFISRFLEGQSG 397

  Fly   129 ---LCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTP--IDLMEGTVCCSIASGAD 188
               ..:|.||..:|||.:.|.:..:||  .|:|.:|.....:...|  ::.:.|.....::.||.
Frog   398 VTIKHVSCGDLFTACLTDRGIIMTFGS--GSNGCLGHANFNDVTQPKIVEDLLGYEIVHVSCGAS 460

  Fly   189 HLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEA------IW 247
            |.:.::...:||:.|..:.|:||..|:.|.:.           |.|:||  ...:||      |.
Frog   461 HAIAVSNEKEVFSWGRGDNGRLGLGSQESYNS-----------PQQVII--PPEYEAQRVVCGID 512

  Fly   248 ATNYCTFMRESQTQVIWATGLNNFKQL-------AHETKGKE-----FALTPIKTE--------L 292
            ::...|...:     :.|.|.|.|.:|       |.|...::     :..|||::.        .
Frog   513 SSMILTVANQ-----LLACGSNRFNKLGFDRILSASEPSSEDQVEEAYTFTPIQSAPLNQEAILC 572

  Fly   293 KDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVC 356
            .|:     |..|:.::|...:|...|..::|:||....:: ...|.:|..|. .|:..|.||:..
Frog   573 ADV-----GTSHSAVVTALGQCYTFGSNQHGQLGTSAHRN-SRVPCLVSALQGVKVTMVACGDAY 631

  Fly   357 SYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKN 395
            :.||..:|::::||.|...:||..|....:..||.:.:|
Frog   632 TVAVGAEGQVFTWGKGARGRLGRRDEGIGIPKIVQLEEN 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	4/13 (31%)
		RCC1	92..141	CDD:278826	13/62 (21%)
		RCC1_2	131..158	CDD:290274	10/26 (38%)
		RCC1	144..193	CDD:278826	11/50 (22%)
		RCC1_2	182..209	CDD:290274	6/26 (23%)
		RCC1	363..414	CDD:278826	10/33 (30%)
nek8	XP_012812229.1	STKc_Nek8	3..258	CDD:270859
		S_TKc	4..256	CDD:214567
		ATS1	320..657	CDD:227511	82/349 (23%)
		RCC1	421..465	CDD:278826	10/45 (22%)
		RCC1	470..517	CDD:278826	15/59 (25%)
		RCC1	587..635	CDD:278826	12/48 (25%)
		RCC1	638..687	CDD:278826	10/33 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010