DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and ca

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster

Alignment Length:	388	Identity:	91/388 - (23%)
Similarity:	143/388 - (36%)	Gaps:	98/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 TRAKPFEAIWATNYCTFMRESQTQVIW-ATGLNNFKQLAHETKGKEFALTPIKTEL-----KDIR 296
            :|.||..|..|  ||..:.:. |...| ::|:.::......|:..|.|......:|     ..:.
  Fly  1115 SRFKPISAGCA--YCACVVDG-TAYFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVH 1176

  Fly   297 HIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVCSYAV 360
            .|..|:.||:|||.:...| :|.....:||:|....:..:|.:|..|. ..|..:..|:..:.||
  Fly  1177 AIKCGRQHTLILTNNGLYS-LGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV 1240

  Fly   361 TIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKA-------- 417
            . |||||.||.|:..|||.|..::...|.:|  ...:.|.:|..|.|..|.:.|..|
  Fly  1241 A-DGKLYMWGWGIYGQLGQGSCENIATPQLV--SFFKFKKILQISLGHAHTLVLCGAPNSHMEAN 1302

  Fly   418 ----------------------DKQDQKENVPVKVS-GSSS-------------ISKKDK----- 441
                                  |..|.|.|:||::. |..|             :.::|:
  Fly  1303 HCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWG 1367

  Fly   442 TPPQ----DNVDKEAENVDKQEQKEN--------------LPAKASTSSK------------KNK 476
            :.||    .|..|...|. ||:.:||              |||...::|.            ...
  Fly  1368 SSPQALRLANQIKRRANA-KQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGS 1431

  Fly   477 TPPQDNAD-KEAENVDKQEQKENLPAKASTSSKKIKTPPQDDAAEEVEEESAQEPTPKKAKKP 538
            ||....:| |:.::|..:....:.....:.:|.|...||...|:..|   ...||.|.:...|
  Fly  1432 TPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPV---LVPEPDPTEHLTP 1491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826
		RCC1	92..141	CDD:278826
		RCC1_2	131..158	CDD:290274
		RCC1	144..193	CDD:278826
		RCC1_2	182..209	CDD:290274
		RCC1	363..414	CDD:278826	19/50 (38%)
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	79/342 (23%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	10/47 (21%)
		RCC1	1242..1291	CDD:278826	19/50 (38%)
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840