DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and CG8060

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	88/404 - (21%)
Similarity:	154/404 - (38%)	Gaps:	121/404 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NNNAGEAEQQ---PPKA----KRARI--------AFH-LELPKRRTVLGNVLVCGNGDVGQLGLG 58
            |.|.|...:|   .|:|    :::.:        |:| |...|:    |::...|:|..|:||:|
  Fly   156 NYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKK----GHLYAVGHGKGGRLGIG 216

  Fly    59 -EDILER-KRL---SPVAGIPDAVD-ISAGGMHNLVLTKSGDIYSFGCNDEGALG-RDTSEDGSE 116
             |:.|.. ||:   |.::|  |::. ||....|:||||....:::.|.|.:..|| ||.:|..::
  Fly   217 LENSLPAPKRVKVSSKLSG--DSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQ 279

  Fly   117 SKPDLIDLPGKA----LCISAGDSH-----SACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRTP- 171
            .| :::.|..|.    :.:.|.|.|     |.|      |:.||:   :.|..|:    |..||
  Fly   280 FK-EVVALRDKGASDLVRVIACDQHSIAYGSRC------VYVWGA---NQGQFGI----NSNTPS 330

  Fly   172 --------------IDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLS------ER 216
                          |..:|.....::....:.::.|..|.|...:.......|..:|      :.
  Fly   331 ITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKN 395

  Fly   217 SISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGK 281
            |..|.....|..:|..|.::.        :|..|...|.|            .||
  Fly   396 STKGSAAALKLLMLTETNVVY--------LWYENTQQFYR------------CNF---------- 430

  Fly   282 EFALTPIKTELKDIRHIAGGQHHTVILTTD-----LKCSVVGRP-----EYGRLGLGDVKDVVEK 336
                :||:  |..|:.|....:..::|:.|     .||:.:..|     |..|..|.:.:|..:.
  Fly   431 ----SPIR--LHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQN 489

  Fly   337 PTIVKKLTEKIVSV 350
            .|.:.:  |.::.:
  Fly   490 KTEISR--EHVIRI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	18/52 (35%)
		RCC1	92..141	CDD:278826	14/58 (24%)
		RCC1_2	131..158	CDD:290274	8/31 (26%)
		RCC1	144..193	CDD:278826	10/63 (16%)
		RCC1_2	182..209	CDD:290274	3/26 (12%)
		RCC1	363..414	CDD:278826
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826	8/38 (21%)
		RCC1	199..251	CDD:278826	18/57 (32%)
		BTB	547..>635	CDD:295341
		BTB	684..795	CDD:279045
		BTB	697..798	CDD:197585
		SPOP_C_like	798..>834	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900