DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and Rcc1l

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001101802.1	Gene:	Rcc1l / 360796	RGDID:	1307558	Length:	461	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	103/448 - (22%)
Similarity:	159/448 - (35%)	Gaps:	128/448 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PKAKRARIAFHLELPKRRTVLGNVLVCGNG---------DVGQ---LGLGEDI---LERKRLSPV 70
            |:.:...:.:.|||..:.    :...||.|         ||.:   :||.:|.   ..|.|....
  Rat    89 PRRRIQPVPYRLELDHKI----SSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKT 149

  Fly    71 AG---------IPDAVD---------ISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSES 117
            .|         :|..:|         :|.|..|:||||....::|.|.|..|..||...||...|
  Rat   150 RGYEYVLEPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNAHGQCGRKVVEDEVYS 214

  Fly   118 KPDLI----DLPGKALCISAGDSHSACLLEDGRVFA--WGSFRDSHGNMGLTIDGNKRTPIDL-- 174
            :...:    |..|:.:.:..|..||..|.:.|.|::  ||    :.|..||.......||..|
  Rat   215 ESHKVHRMQDFEGQVVQVVCGQDHSLFLTDKGEVYSCGWG----ADGQTGLGHYNITSTPSKLGG 275

  Fly   175 -MEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIIT 238
             :.|.....:|:..|..:.|:..|.||..|.:|..||..:::                .||:.:.
  Rat   276 DLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTD----------------STQVNVP 324

  Fly   239 RAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQH 303
            |..||..:                                 ||             ::.:|.|..
  Rat   325 RCLPFSGV---------------------------------GK-------------VKQVACGGT 343

  Fly   304 HTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKK----LTE-----KIVSVGCGEVCSYA 359
            ...||..:....|.|   ||.||.|........|.::..    |||     |:..:.||.....|
  Rat   344 GCAILNEEGHVFVWG---YGILGKGPNLSETALPEMIPPTLFGLTEFNPEVKVSQIRCGLSHFAA 405

  Fly   360 VTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKA 417
            :|..|:|:.||..:...||:|..:|:..|..|   ...|:.:.:|. |..|.:.|.|:
  Rat   406 LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV---TMPGEPVDVAC-GVDHMVTLAKS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	17/79 (22%)
		RCC1	92..141	CDD:278826	14/52 (27%)
		RCC1_2	131..158	CDD:290274	8/28 (29%)
		RCC1	144..193	CDD:278826	13/53 (25%)
		RCC1_2	182..209	CDD:290274	8/26 (31%)
		RCC1	363..414	CDD:278826	14/50 (28%)
Rcc1l	NP_001101802.1	RCC1	127..186	CDD:278826	12/58 (21%)
		RCC1_2	173..202	CDD:290274	10/28 (36%)
		RCC1	192..242	CDD:278826	14/49 (29%)
		RCC1_2	229..258	CDD:290274	8/32 (25%)
		RCC1	245..295	CDD:278826	13/53 (25%)
		RCC1	298..348	CDD:278826	16/111 (14%)
		RCC1_2	393..422	CDD:290274	8/28 (29%)
		RCC1	409..452	CDD:278826	13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910