DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and herc1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_009301513.1	Gene:	herc1 / 336598	ZFINID:	ZDB-GENE-030131-8542	Length:	4867	Species:	Danio rerio

Alignment Length:	394	Identity:	95/394 - (24%)
Similarity:	154/394 - (39%)	Gaps:	107/394 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNVLVCGNGDVGQLGLG----EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCND 102
            |:|..||.|..|:||||    :..|::....|...|...........|.|..|..|:::|:|..|
Zfish   417 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRAIKKVSSSKGSDGHTLAFTSEGEVFSWGDGD 481

  Fly   103 EGALGRDTSEDGSESKPDLID--LPGK-ALCISAGDSHSACLLEDGRVFAWGS---FRDSHGNMG 161
            .|.||...|  .::..|.||.  |.|| .:|:|||..|||.:.|||.::.||.   .|..||
Zfish   482 YGKLGHGNS--STQKYPKLIQGPLQGKVVVCVSAGYRHSAAVSEDGELYTWGEGDFGRLGHG--- 541

  Fly   162 LTIDGNKRTPIDLME-----GTVCCSIASGADHLVILTTAGK-VFTVGCAEQGQLGRLSERSISG 220
               |.|.|....|::     |.|.|    |:.|.:.|:..|: |::.|..:.|:||.       |
Zfish   542 ---DSNSRNIPTLVKDISNVGEVSC----GSSHTIALSKDGRTVWSFGGGDNGKLGH-------G 592

  Fly   221 EGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFAL 285
            :..|            :.:.|..||:                   .|:
Zfish   593 DTNR------------VYKPKVVEAL-------------------QGM----------------- 609

  Fly   286 TPIKTELKDIRHIAGGQHHTVILTTDLK-----CSVVGRPEYGRLGLGDVKDVVEKPTIVKKL-T 344
                    .||.:..|...::.||:..:     |...       ||.|..:....:|.::::| |
Zfish   610 --------FIRKVCAGSQSSLALTSTGQVYAWGCGAC-------LGCGSSEATALRPKLIEELAT 659

  Fly   345 EKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDEL-EPIVVVSKNTQGKHMLLASGGG 408
            .::|.:..|:....|::.|.::|:||:....|.|.|:....: :|..|:  ...|..:...|.|.
Zfish   660 TRVVDISIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVI--GLDGVAIQQISAGT 722

  Fly   409 QHAI 412
            .|::
Zfish   723 SHSL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	15/50 (30%)
		RCC1	92..141	CDD:278826	21/51 (41%)
		RCC1_2	131..158	CDD:290274	12/29 (41%)
		RCC1	144..193	CDD:278826	16/56 (29%)
		RCC1_2	182..209	CDD:290274	6/27 (22%)
		RCC1	363..414	CDD:278826	13/51 (25%)
herc1	XP_009301513.1	RCC1	369..726	CDD:332518	95/392 (24%)
		SPRY_HERC1	2004..2161	CDD:293939
		UBA_HERC1	2729..2772	CDD:270584
		WD40	3406..3773	CDD:330360
		WD40 repeat	3419..3452	CDD:293791
		WD40 repeat	3479..3514	CDD:293791
		WD40 repeat	3527..3569	CDD:293791
		WD40 repeat	3575..3611	CDD:293791
		WD40 repeat	3618..3660	CDD:293791
		WD40 repeat	3665..3710	CDD:293791
		WD40	3737..>3831	CDD:330360
		WD40 repeat	3749..3784	CDD:293791
		RCC1	4004..4351	CDD:332518
		HECTc	4479..4847	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840