DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and Herc2

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_006229362.1	Gene:	Herc2 / 308669	RGDID:	1307989	Length:	4836	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	125/497 - (25%)
Similarity:	190/497 - (38%)	Gaps:	93/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LPKRRTVLGNVLVCGNGDVGQL-GLGEDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYS 97
            |....|:...|.|.|..|..|| ||....::....|......:.|.::.|......:|..|.:||
  Rat  2952 LESTATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYS 3016

  Fly    98 FGCNDEGALGRDTSEDGSESKPDLIDLPG----KALCISAGDSHSACLLEDGRVFAWGSFRDSHG 158
            .|....|.||...| .|:...|..|....    |.:.:.:|..|:..|..||:||:||...|  |
  Rat  3017 CGEATNGRLGLGMS-SGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD--G 3078

  Fly   159 NMG--LTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGE 221
            .:|  ..::.:|...|:.::......||.|:.|...||::|:::|.|..|.|:||.       |:
  Rat  3079 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH-------GD 3136

  Fly   222 GRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGL------NNFKQLAHETKG 280
                     ..|||.....|..............|::||..:...||      .:|.:|..  .|
  Rat  3137 ---------NTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGR--GG 3190

  Fly   281 KEFALTPIKTEL---KDIRHIAGGQHHTVILTTDLKCSVV---GRPEYGRLGLGDVKDV-VEKPT 338
            .|....|...|.   :.:..|..|...::.||   |..||   |:.:|.|||.|  .|| |.||.
  Rat  3191 SEGCNIPQNIERLNGQGVCQIECGAQFSLALT---KSGVVWTWGKGDYFRLGHG--SDVHVRKPQ 3250

  Fly   339 IVKKLT-EKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHML 402
            :|:.|. :|||.|..|.:...|||..|::|:||...:.|.|.|......:|.:|  :..:|:.:.
  Rat  3251 VVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLV--QGLEGQKIT 3313

  Fly   403 LASGGGQHAIFLVKADKQDQKENVPVKVS------GSSSISKKDKTPPQDNVDKEAENVDKQEQK 461
            ..:.|..|::.....|......:.||...      |:|.:
  Rat  3314 RVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYL------------------------- 3353

  Fly   462 ENLPAKASTSSKKNKTPPQDNADKEAENVDKQEQKENLPAKA 503
             .:|:.|.:||..||.....|.            |.|.|:.|
  Rat  3354 -GVPSDADSSSSSNKISGVSNC------------KPNRPSLA 3382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	11/47 (23%)
		RCC1	92..141	CDD:278826	14/52 (27%)
		RCC1_2	131..158	CDD:290274	10/26 (38%)
		RCC1	144..193	CDD:278826	15/50 (30%)
		RCC1_2	182..209	CDD:290274	10/26 (38%)
		RCC1	363..414	CDD:278826	12/50 (24%)
Herc2	XP_006229362.1	ATS1	<494..787	CDD:227511
		Cyt-b5	1212..1283	CDD:395121
		MIB_HERC2	1871..1931	CDD:399589
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:402903
		SH3_15	2640..2697	CDD:408152
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		ATS1	2957..3323	CDD:227511	108/393 (27%)
		ATS1	4025..4330	CDD:227511
		HECTc	4423..4794	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820