DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcc1 and Herc1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_006511166.1	Gene:	Herc1 / 235439	MGIID:	2384589	Length:	4885	Species:	Mus musculus

Alignment Length:	417	Identity:	100/417 - (23%)
Similarity:	166/417 - (39%)	Gaps:	90/417 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNVLVCGNGDVGQLGLG--EDILERKRLSPVAG--IPDAVDISAGGMHNLVLTKSGDIYSFGCND 102
            |.||.||.|..|:||.|  :|:.....:|.:.|  :...|.......|::.||:||:::|:|..|
Mouse  4070 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4134

  Fly   103 EGALGRDTSEDGSESKPDLID-LPGKALC-ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTID 165
            .|.||...|:  .:.:|..|: |.|:.:. :|.|..|||.:..||::|.:|:  ..:|.:||...
Mouse  4135 YGKLGHGNSD--RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--GDYGRLGLGNT 4195

  Fly   166 GNKRTP--IDLMEGTVCCSIASGADHLVILTTAGK-VFTVGCAEQGQLGRLSERSISGEGRRGKR 227
            .||:.|  :..:||.....:|.|.:|.:.::..|. |:..|..:.|:||..:..:
Mouse  4196 SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---------- 4250

  Fly   228 DLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTEL 292
                       ::.|               .:..|:...|
Mouse  4251 -----------KSSP---------------QKVDVLCGIG------------------------- 4264

  Fly   293 KDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIV-SVGCGEVC 356
              |:.:|.|...:|.||.|......|:.....|..|..:: ..:|..:..|...:: .|..|...
Mouse  4265 --IKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARN-HNRPQQIPVLAGVVIEDVAVGAEH 4326

  Fly   357 SYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQD 421
            :.|:...|.:|:|||....|||:|..:...||.:|..  .|||::...|.|..|:.......
Mouse  4327 TLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTV--LQGKNIRQISAGRCHSAAWTAPP--- 4386

  Fly   422 QKENVPVKVSGSS---SISKKDKTPPQ 445
                ||.:..|.|   .:...|..|||
Mouse  4387 ----VPPRAPGVSVPLQLGLPDAVPPQ 4409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	15/50 (30%)
		RCC1	92..141	CDD:278826	18/50 (36%)
		RCC1_2	131..158	CDD:290274	9/26 (35%)
		RCC1	144..193	CDD:278826	15/50 (30%)
		RCC1_2	182..209	CDD:290274	6/27 (22%)
		RCC1	363..414	CDD:278826	18/50 (36%)
Herc1	XP_006511166.1	ATS1	374..731	CDD:227511
		SPRY_HERC1	2039..2196	CDD:293939
		UBA_HERC1	2760..2803	CDD:270584
		WD40	3448..3799	CDD:392136
		WD40 repeat	3456..3499	CDD:293791
		WD40 repeat	3513..3548	CDD:293791
		WD40 repeat	3610..3648	CDD:293791
		WD40 repeat	3653..3689	CDD:293791
		WD40 repeat	3697..3736	CDD:293791
		WD40 repeat	3774..3810	CDD:293791
		ATS1	4022..4370	CDD:227511	89/369 (24%)
		HECTc	4497..4865	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840