DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and nek8

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	357	Identity:	88/357 - (24%)
Similarity:	151/357 - (42%)	Gaps:	60/357 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSES-KPDLID--LPGKA----LCIS 132
            :.:.:|.|....:.:||||.:.::.....|: |..|.....|. :|..|.  |.|::    ..:|
Zfish   341 EVIQVSLGRTQKMGVTKSGRLITWEAPSVGS-GEPTLPGAVEQMQPQFISRFLEGQSGVTIKSVS 404

  Fly   133 AGDSHSACLLEDGRVFAWGSFRD---SHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILT 194
            .||..:.||.:.|.:..:||..:   .|||..   |..:...::.:.|.....::.||.|::.:|
Zfish   405 CGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFN---DVTQPKIVEALLGYELVQVSCGASHVLAVT 466

  Fly   195 TAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEA--IWATNYCTFMRE 257
            ...:||:.|..:.|:||..::.|.:           .|.|  ::....|||  :.....|:.:..
Zfish   467 NEREVFSWGRGDNGRLGLATQDSHN-----------CPQQ--VSLPADFEAQRVLCGVDCSMIMS 518

  Fly   258 SQTQVIWATGLNNFKQLA-HETKGKE-------------FAL---TPIKTELKDIRHIAGGQHHT 305
            :|.|:: |.|.|.|.:|. .:..|.|             |.|   .|:.||  .|.:|..|..|:
Zfish   519 TQHQIL-ACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTE--KIVYIDIGTAHS 580

  Fly   306 VILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWG 370
            |.:|...:|...|..::|:||....:. ...|..|..| :.|....||:..:.|:..:|::|:||
Zfish   581 VAVTEKGQCFTFGSNQHGQLGCSHRRS-SRVPYQVSGL-QGITMAACGDAFTLAIGAEGEVYTWG 643

  Fly   371 SGVNNQLGVGDGD---------DELEPIVVVS 393
            .|...:||..:.|         ||.....|.|
Zfish   644 KGARGRLGRKEEDFGIPKPVQLDESHAFTVTS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	2/13 (15%)
		RCC1	92..141	CDD:278826	13/55 (24%)
		RCC1_2	131..158	CDD:290274	8/29 (28%)
		RCC1	144..193	CDD:278826	11/51 (22%)
		RCC1_2	182..209	CDD:290274	7/26 (27%)
		RCC1	363..414	CDD:278826	12/40 (30%)
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859
		S_TKc	4..255	CDD:214567
		ATS1	309..662	CDD:227511	84/342 (25%)
		RCC1 1	417..468		12/53 (23%)
		RCC1 2	469..520		13/63 (21%)
		RCC1 3	521..586		19/67 (28%)
		RCC1 4	587..636		12/50 (24%)
		RCC1 5	637..689		12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010