DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rcc1 and Rcc1

DIOPT Version :9

Sequence 1:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001184011.1	Gene:	Rcc1 / 100088	MGIID:	1913989	Length:	434	Species:	Mus musculus

Alignment Length:	432	Identity:	180/432 - (41%)
Similarity:	251/432 - (58%)	Gaps:	27/432 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRRKALTNNNNAGEAEQQPPKAKRARIAFHLELPKRRTVLGNVLVCGNGDVGQLGLGEDILERK 65
            :|:.|.:.:..|.|.|.:....:.|:          ..|..|.||..|.||||||||||.:||||
Mouse    17 IPKSKKVKDTRNRGPATRSCQVSHRS----------HNTEPGLVLTLGQGDVGQLGLGESVLERK 71

  Fly    66 RLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALC 130
            :.:.|..:.|.|...|||||.:.|::||.:||||||||||||||||.:|||..|..::|..|.:.
Mouse    72 KPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQ 136

  Fly   131 ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKRT--PIDLMEGTVCCSIASGADHLVIL 193
            :||||||:|.|.||||||.||||||::|.:|| ::..|::  |:.:........:|||.||||:|
Mouse   137 VSAGDSHTAALTEDGRVFLWGSFRDNNGVIGL-LEPMKKSMVPVQVQLDAPVVKVASGNDHLVML 200

  Fly   194 TTAGKVFTVGCAEQGQLGRLSERSISGEGRRGKRDLLRPTQLII----TRAK-PFEAIWATNYCT 253
            |..|.::|:||.|||||||:.|...:..||:|...||.|..:::    ||.: .|:..:...|.|
Mouse   201 TNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFT 265

  Fly   254 F--MRESQTQVIWATGLNNFKQLAHETKGKEFA---LTPIKTELKDIRHIAGGQHHTVILTTDLK 313
            |  .||..   ::..||:|:.||.....|..|.   ||..|...|.....:|||||||.:.::.|
Mouse   266 FAISREGH---VYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK 327

  Fly   314 CSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLG 378
            ...:||.||||||||:..:....||::.:| ..:.||.||....|||:.||::::||.|.|.|||
Mouse   328 AYSLGRAEYGRLGLGEGAEEKSIPTLISRL-PVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLG 391

  Fly   379 VGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQ 420
            .|..:|...|:.:..|..:.:.:|..|.||||.:.|||...|
Mouse   392 TGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDQAQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	26/46 (57%)
		RCC1	92..141	CDD:278826	31/48 (65%)
		RCC1_2	131..158	CDD:290274	20/26 (77%)
		RCC1	144..193	CDD:278826	23/50 (46%)
		RCC1_2	182..209	CDD:290274	15/26 (58%)
		RCC1	363..414	CDD:278826	19/50 (38%)
Rcc1	NP_001184011.1	RCC1	48..95	CDD:278826	22/46 (48%)
		RCC1	98..147	CDD:278826	29/48 (60%)
		RCC1	150..200	CDD:278826	23/51 (45%)
		RCC1_2	187..216	CDD:290274	11/28 (39%)
		RCC1	203..268	CDD:278826	27/69 (39%)
		RCC1	271..322	CDD:278826	18/53 (34%)
		RCC1	325..368	CDD:278826	16/42 (38%)
		RCC1	376..427	CDD:278826	19/50 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55567
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2574
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58672
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0004765
OrthoInspector	1	1.000	-	-		oto94038
orthoMCL	1	0.900	-	-		OOG6_100545
Panther	1	1.100	-	-	LDO	PTHR45982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1072
SonicParanoid	1	1.000	-	-		X2826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800