DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33523 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_001261457.1	Gene:	CG33523 / 38668	FlyBaseID:	FBgn0053523	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	502	Identity:	98/502 - (19%)
Similarity:	162/502 - (32%)	Gaps:	171/502 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TPQQIEELRDRFNRKYASSP-------------PAAPFHPTDIDRIRNDHL-------------- 46
            ||..:.| .|..|:.....|             ||......|.|::..|::
Human   182 TPAPVRE-EDARNQAGPRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQESC 245

  Fly    47 ------WLQ--------------RFLEMYDLDMETSFNSLWETCILRQSTG---ANDID------ 82
                  |||              |||..:|..::.:..      :||||..   .:.:|
Human   246 LIQLRHWLQETHKGKIPKDEHILRFLRAHDFHLDKARE------MLRQSLSWRKQHQVDLLLQTW 304

  Fly    83 -ESELNQEYLKEGSVFVHNTDVDGKPLLVFRV-----KMHSKSKNLDELIRIVVYWVERTQRE-- 139
             ...|.:|:...|   .|..|:||:||.:.|:     |...|:...:.|:|.|:...|..|:.
Human   305 QPPALLEEFYAGG---WHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCE 366

  Fly   140 -------QHLTQLTIFFDMSGTSLASMDLEFVK---RIVETFKQFYPNSLNYILVYELGWVLNAA 194
                   :.::..|...|:.|.::..:....||   |::|..:..||.:|..:|:
Human   367 GSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLI---------- 421

  Fly   195 FKVIKAVLPPKAVEILKMISKKDINQYINKDNCLAIWGGEDNYEFSFVPEAKKVISKPVAANAGD 259
                  |..|:...:|..:....||:  |......|:.| .||:                 ..|.
Human   422 ------VRAPRVFPVLWTLISPFINE--NTRRKFLIYSG-SNYQ-----------------GPGG 460

  Fly   260 DDQFADKKV--TFVDS-----------APMVLKETNINKMHTP----------SEGMLHINPKDF 301
            ...:.|::|  .|:..           .|..|..|...:.||.          |..:|...|.:
Human   461 LVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLWQWSETYHSASVLRGAPHE- 524

  Fly   302 VNFNSKNAEATMTIK-SIATSAVTYKIQTTSPEKFRVRPRCGIIQPNQEATINI----WLKSEHK 361
            |.......|:.:|.. .|....|.:.:..|     :..||.|..:|...|:..:    |:.
Human   525 VAVEILEGESVITWDFDILRGDVVFSLYHT-----KQAPRLGAREPGTRASGQLIDKGWVL---- 580

  Fly   362 LSDDSKDKFLVMA-MVAPGGE-CGGADVTE-------LWRSKSPTSA 399
                .:|...|.| :|...|| ..|:.||.       .|:..||.|:
Human   581 ----GRDYSRVEAPLVCREGESIQGSHVTRWPGVYLLQWQMHSPPSS 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33523	NP_001261457.1	CRAL_TRIO	94..234	CDD:279044	33/156 (21%)
CG33523	NP_001261457.1	Motile_Sperm	293..396	CDD:279029	24/116 (21%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		6/32 (19%)
		CRAL_TRIO_N	243..288	CDD:215024	9/50 (18%)
		SEC14	306..479	CDD:214706	42/211 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810