DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33523 and TTPAL

DIOPT Version :9

Sequence 1:	NP_001261457.1	Gene:	CG33523 / 38668	FlyBaseID:	FBgn0053523	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001034288.1	Gene:	TTPAL / 79183	HGNCID:	16114	Length:	342	Species:	Homo sapiens

Alignment Length:	294	Identity:	59/294 - (20%)
Similarity:	106/294 - (36%)	Gaps:	57/294 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QQIEELRDRFNRKYASSPPAAPFHPTDIDRIRNDHLWLQRFLEMYDLDMETSFNSL--WETCILR 73
            :.::.|||...::|       |...|.:     |..:|.|||.....|.:.:...|  :.:|...
Human    56 RDVQALRDMVRKEY-------PNLSTSL-----DDAFLLRFLRARKFDYDRALQLLVNYHSCRRS 108

  Fly    74 QSTGANDIDESELNQEYLKEG--SVFVHNTDVDGKPLLVFRVKMHSKSK-NLDELIRIVVYWVER 135
            .....|::..|.| ::.|..|  :|..| ||..|..::..|......|. .:.|.||.:...:|:
Human   109 WPEVFNNLKPSAL-KDVLASGFLTVLPH-TDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEK 171

  Fly   136 --TQREQHLTQLTIFFDMSGTSL--ASMDLEFV-KRIVETFKQFYPNSLNYILVYELGWVLNAAF 195
              ...|..:..:.|..|..|.||  ||....|: |:::...:..:|..:..:.|.....:....|
Human   172 LIQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHVVNEPRIFKGIF 236

  Fly   196 KVIKAVLPPKAVEILKMISKKDINQYINKDNCLAIWGGEDNYEFSFVPEAKKVISKPVAANAGD- 259
            .:||..|..|..                  |...:.|.:.|...:.:|  :.::.|.....||:
Human   237 AIIKPFLKEKIA------------------NRFFLHGSDLNSLHTNLP--RSILPKEYGGTAGEL 281

  Fly   260 ------------DDQFADKKVTFVDSAPMVLKET 281
                        :|.|..:....|.:...:|.:|
Human   282 DTATWNAVLLASEDDFVKEFCQPVPACDSILGQT 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33523	NP_001261457.1	CRAL_TRIO	94..234	CDD:279044	31/147 (21%)
CG33523	NP_001261457.1	Motile_Sperm	293..396	CDD:279029
TTPAL	NP_001034288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		CRAL_TRIO_N	56..102	CDD:215024	13/57 (23%)
		SEC14	121..277	CDD:238099	36/177 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900