DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33523 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001261457.1	Gene:	CG33523 / 38668	FlyBaseID:	FBgn0053523	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	467	Identity:	88/467 - (18%)
Similarity:	169/467 - (36%)	Gaps:	148/467 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSPPAA--PFHPTDIDRIRNDHL--------------------WLQ--------------RFLEM 54
            |||..|  |...|..|::..|::                    |||              |||..
Mouse   222 SSPGTASEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILRFLRA 286

  Fly    55 YDLDMETSFNSLWETCILRQSTGANDIDES----ELNQEYLKEGSVFVHNTDVDGKPLLVFRV-K 114
            .|.:::.:...:.::...|:....:.|.::    ::..:|...|   .|:.|.||:||.|.|: :
Mouse   287 RDFNIDKAREIMCQSLTWRKQHQVDYILDTWTPPQVLLDYYAGG---WHHHDKDGRPLYVLRLGQ 348

  Fly   115 MHSKS--KNLDE--LIRIVVYWVERTQRE---------QHLTQLTIFFDMSGTSLASMDLEFVK- 165
            |.:|.  :.|.|  |:|.|:...|...|.         :.::..|...|:.|.::..:....||
Mouse   349 MDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKA 413

  Fly   166 --RIVETFKQFYPNSLNYILVYELGWVLNAAFKVIKAVLPPKAVEILKMISKKDINQYINKDNCL 228
              ||:|..:..||.:|..:|             :::|   |:...:|..:    ::.:|
Mouse   414 LLRIIEVVEANYPETLGRLL-------------ILRA---PRVFPVLWTL----VSPFI------ 452

  Fly   229 AIWGGEDNYEFSFVPEAKKVISKPVAANAGDDDQ-------FADKKV--TFVDSAPMVLKETNIN 284
                 :||....|:            ..||:|.|       :.||::  .|:....|
Mouse   453 -----DDNTRRKFL------------IYAGNDYQGPGGLLDYIDKEIIPDFLSGECM-------- 492

  Fly   285 KMHTPSEGMLHINPKDFVNF--NSKNAEATMTIKSIATSAVTYKIQTTSPEKFRVRPRCGIIQPN 347
             ...|..|::   ||.....  ..:|.:..:..::|..||..:|   .:|.:..::    |:..:
Mouse   493 -CDVPEGGLV---PKSLYRTAEELENEDLKLWTETIYQSASVFK---GAPHEILIQ----IVDAS 546

  Fly   348 QEAT-----------INIWLKSEHKLSDDSKDKFLVMAMVAPGGECGGADVTELWRSKSPTSADV 401
            ...|           .||: .|:.......||.....::.:|||. ....:.::|:.....|  :
Mouse   547 SVITWDFDVCKGDIVFNIY-HSKRSPQPPKKDSLGAHSITSPGGN-NVQLIDKVWQLGRDYS--M 607

  Fly   402 EQHRLVCRFDEN 413
            .:..|:|:..|:
Mouse   608 VESPLICKEGES 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33523	NP_001261457.1	CRAL_TRIO	94..234	CDD:279044	34/156 (22%)
CG33523	NP_001261457.1	Motile_Sperm	293..396	CDD:279029	19/115 (17%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		67/345 (19%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	7/44 (16%)
		CRAL_TRIO	326..490	CDD:279044	45/209 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810