DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33523 and SEC14L1

DIOPT Version :9

Sequence 1:	NP_001261457.1	Gene:	CG33523 / 38668	FlyBaseID:	FBgn0053523	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	491	Identity:	94/491 - (19%)
Similarity:	178/491 - (36%)	Gaps:	153/491 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKVKETTPQQIEELRDRFNRKYASSPPA-APFHPTDIDRIRNDHL------------------ 46
            |.|.:.|..      |::..:....|||.| .|...|..|::..|::
Human   204 MAVVIPEAA------LKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRL 262

  Fly    47 --WLQ--------------RFLEMYDLDMETSFNSLWETCILRQSTGANDIDES----ELNQEYL 91
              |||              |||...|.:::.:...:.::...|:....:.|.|:    ::.|:|.
Human   263 RQWLQETHKGKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQDYY 327

  Fly    92 KEGSVFVHNTDVDGKPLLVFRV-KMHSKS--KNLDE--LIRIVVYWVERTQRE---------QHL 142
            ..|   .|:.|.||:||.|.|: :|.:|.  :.|.|  |:|.|:...|...|.         :.:
Human   328 AGG---WHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPI 389

  Fly   143 TQLTIFFDMSGTSLASMDLEFVK---RIVETFKQFYPNSLNYILVYELGWVLNAAFKVIKAVLPP 204
            :..|...|:.|.::..:....||   ||:|..:..||.:|..:|             :::|   |
Human   390 SSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLL-------------ILRA---P 438

  Fly   205 KAVEILKMISKKDINQYINKDNCLAIWGGEDNYEFSFVPEAKKVISKPVAANAGDDDQ------- 262
            :...:|..:    ::.:|           :||....|:            ..||:|.|
Human   439 RVFPVLWTL----VSPFI-----------DDNTRRKFL------------IYAGNDYQGPGGLLD 476

  Fly   263 FADKKV--TFVDSAPMVLKETNINKMHTPSEGMLHINPKDFVNF--NSKNAEATMTIKSIATSAV 323
            :.||::  .|:....|         ...|..|::   ||.....  ..:|.:..:..::|..||.
Human   477 YIDKEIIPDFLSGECM---------CEVPEGGLV---PKSLYRTAEELENEDLKLWTETIYQSAS 529

  Fly   324 TYKIQTTSPEKFRVRPRCGIIQPNQEAT-----------INIWLKSEHKLSDDSKDKFLVMAMVA 377
            .:|   .:|.:..::    |:..:...|           .||: .|:.......||.....::.:
Human   530 VFK---GAPHEILIQ----IVDASSVITWDFDVCKGDIVFNIY-HSKRSPQPPKKDSLGAHSITS 586

  Fly   378 PGGECGGADVTELWRSKSPTSADVEQHRLVCRFDEN 413
            |||. ....:.::|:.....|  :.:..|:|:..|:
Human   587 PGGN-NVQLIDKVWQLGRDYS--MVESPLICKEGES 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33523	NP_001261457.1	CRAL_TRIO	94..234	CDD:279044	34/156 (22%)
CG33523	NP_001261457.1	Motile_Sperm	293..396	CDD:279029	19/115 (17%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	7/44 (16%)
		CRAL_TRIO	326..490	CDD:366224	45/209 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810