DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33523 and hpo-28

DIOPT Version :9

Sequence 1:	NP_001261457.1	Gene:	CG33523 / 38668	FlyBaseID:	FBgn0053523	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_498232.3	Gene:	hpo-28 / 175798	WormBaseID:	WBGene00015148	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	135/529 - (25%)
Similarity:	234/529 - (44%)	Gaps:	93/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IEELRDRFNRKYASSPPAAPFH-PTDIDRIRNDHLWLQRFLEMYDLDMETSFNSLWETCILRQST 76
            :.|||.|.    ...|..:..| ..|:.|||::..||.|||...:.|::.::..:.|....|::.
Worm    27 VHELRSRI----LQDPAISVKHLSDDVHRIRHEDWWLDRFLGSVNYDVDIAYAIMLECLKWRRNF 87

  Fly    77 GANDIDESELNQEYLKEGSVFVHNTDVDGKPLLVFRVKMHSKSKNLDE-LIRIVVYWVERTQREQ 140
            ..:.|....| :..|....:::|..|:..:.:|..   |.:|.||.|: ..::..:|:||...|.
Worm    88 EVDRISLLSL-KPLLDNQLMYLHGKDLQNRHMLWI---MMNKYKNGDDGFEKLFTFWIERHYMEY 148

  Fly   141 HLTQ-LTIFFDMSGTSLASMDLEFVKRIVETFKQFYPNSLNYILVYELGWVLNAAFKVIKAVLPP 204
            ...| ||:|.||:||.|.:|..:.:|.|:.:.|.:||||:..||::|...:|||::|||.:.|..
Worm   149 KGCQPLTVFIDMTGTGLKNMSFDAMKFIIHSSKYYYPNSIESILIFENPAILNASWKVIGSWLES 213

  Fly   205 KAV----EILKMISKKDINQYINKDNCLAIWGGEDNYEFSFVPEAKKVISKPVAANAG------- 258
            .|.    ::|..::|..:..|:.|.:.|...||.|.::|: :.|..|.:..|......
Worm   214 SAASQRHDLLTFVTKLSVTHYVPKSHLLEHQGGTDTFKFT-MDELAKCLPPPPPPKPSPKLLQQR 277

  Fly   259 ---------------DDDQFADKKVTFVDSA-----------------------PMVLKETNINK 285
                           |...|..:.|.|.:.:                       |..|:....|:
Worm   278 MHSIDDSTNNNVTEFDFSSFQKRNVKFDEESTTKRAPSLSRRSSRGPKSRKSHIPPSLRPLIENR 342

  Fly   286 MHTPSE-----GMLHINPKDFVNFNSKNAE-----ATMTIKSIATSAVTYKIQTTSPEKFRVRPR 340
            ::.||:     ..:.|.|:|.:.....:.|     ..:.....:.:.:.:|.:|||||||||||.
Worm   343 VNAPSDDWSSNDFVSITPRDELRLEKLDGENDLLDVVLVKNQSSDTPIMFKFKTTSPEKFRVRPS 407

  Fly   341 CGIIQPNQEATINIWLKSEHKLSDDSKDKFLVMAMVAPGGECGGADVTELWRSKSPTSADVEQHR 405
            .||:||.....|.::|:.|::.| .:|:|||::.|     |....|| |.:..:..::::..:.:
Worm   408 SGIVQPGTTEIIRVYLQYEYRHS-WNKEKFLLLTM-----ESSSTDV-ESFSEQFKSASNKAEFK 465

  Fly   406 LVCRFDENKSKAQLDCASKSS---KASVDCSKKSGAGVDPATAMERQLAFTQNLQYVTLAL-LFL 466
            ..||..||....|.: ..:||   :.....||..|..:.         .|...|..:||.| |||
Worm   466 FKCRLSENLKLDQPE-ERRSSFLLQQQQLLSKPEGFSLG---------GFNIYLPIITLILFLFL 520

  Fly   467 LFAGFGFLM 475
            :|. |.:::
Worm   521 IFQ-FSYIL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33523	NP_001261457.1	CRAL_TRIO	94..234	CDD:279044	46/145 (32%)
CG33523	NP_001261457.1	Motile_Sperm	293..396	CDD:279029	33/107 (31%)
hpo-28	NP_498232.3	SEC14	105..247	CDD:238099	46/144 (32%)
hpo-28	NP_498232.3	Motile_Sperm	<381..460	CDD:279029	29/85 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159699
Domainoid	1	1.000	79	1.000	Domainoid score	I5614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22125
Inparanoid	1	1.050	139	1.000	Inparanoid score	I3086
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49365
OrthoDB	1	1.010	-	-		D217631at33208
OrthoFinder	1	1.000	-	-		FOG0002427
OrthoInspector	1	1.000	-	-		otm14425
orthoMCL	1	0.900	-	-		OOG6_101230
Panther	1	1.100	-	-	LDO	PTHR46384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910