DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10483 and XPR1

DIOPT Version :9

Sequence 1:NP_648000.1 Gene:CG10483 / 38666 FlyBaseID:FBgn0035649 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_004727.2 Gene:XPR1 / 9213 HGNCID:12827 Length:696 Species:Homo sapiens


Alignment Length:675 Identity:367/675 - (54%)
Similarity:472/675 - (69%) Gaps:47/675 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKFAEHLTAHITPEWRKQYINYEEMKAMLYAAIEQSPSAELVEREMVTRYFAKFDEEFFHYCDKE 65
            |||||||:||||||||||||.||..|.|||:|.:|:||.|:.:.:.|.||||||:|:||..|:||
Human     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LAKINTFYSEKMAEATRKYGSLRSELTEALEMGHPKKLPAWK----------RRTPL----GKKN 116
            |||||||||||:|||.|::.:|::||..:|:        |.|          ||.|:    .::.
Human    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLD--------AQKESTGVTTLRQRRKPVFHLSHEER 122

  Fly   117 VPARKIQDLKLAFSEFYLGLILLQNYQNLNFTGFRKILKKHDKLLSVDYGARWRTDHVEAAHFYT 181
            |..|.|:|||||||||||.||||||||||||||||||||||||:|....||.||..|||.|.|||
Human   123 VQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYT 187

  Fly   182 NKDIDRLIQETEQAVTQDIEGGDRQRAMKRLRVPPLG-EQQSP-WTTFKVGLFSGAFVVLFITVV 244
            .|.|::||.|||..||.::|.||||:||||||||||| .|.:| ||||:||||.|.|:||.||:|
Human   188 CKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLV 252

  Fly   245 IAAMFYGFGEN--WRAGMRMFRAPFLIIECLFLWGVNVYGWRSSGVNHVLIFELDPRNHLSEQNI 307
            :||:|....:.  |.. :|::|..||:||.|||.|:|.||||.:||||||||||:||::||.|::
Human   253 LAAVFKLETDRSIWPL-IRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHL 316

  Fly   308 MEVASVFGVIWACCVLSYIFCDPLGIPQYAAPLCLYTLMAAFLLNPTKTFHHEARFWAIRILIRV 372
            .|:|...|::|...:|:..|.....||.|..||.||..|..||:||||||::::|||.:::|.||
Human   317 FEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRV 381

  Fly   373 IMAPFCFVNFADFWLADQLNSMVPAFLDIPFLICFFGRSPTWHKA-------GKAASHCVEYVSL 430
            ..|||..|.||||||||||||:....:|:.::|||:.....|.::       .:.:..|.:|...
Human   382 FTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYG 446

  Fly   431 LHPIVAIMPAYFRFAQCIRRYRDTKESFPHLVNAAKYATSFFVVIFA-----HKYHTTTDTYPLS 490
            :..||..:||:.||.||:|||||||.:|||||||.||:|:||:|.||     ||....:||.   
Human   447 VRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTM--- 508

  Fly   491 KENPWFYCWITAAIFSSCYAYTWDIKMDWGLFDSKAGDNRFLREEIVYSSTWFYYFGIIEDLILR 555
               .:||.||...|.||||...||:||||||||..||:|.||||||||....:||..||||:|||
Human   509 ---VFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILR 570

  Fly   556 FSWTLSMSLIEAGYI--EGDVMMTILSPLEVFRRFIWNYFRLENEHLNNVGKFRAVRDISVAPMD 618
            |:||:.:|:.....:  .||::.|:.:||||||||:||:||||||||||.|:|||||||||||::
Human   571 FAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLN 635

  Fly   619 CSDQTTILRMMDETDGVLNRRRGKA 643
            ..|||.:.:|||:.|||.||::.::
Human   636 ADDQTLLEQMMDQDDGVRNRQKNRS 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10483NP_648000.1 SPX_XPR1_like 2..159 CDD:269898 102/170 (60%)
SPX 3..162 CDD:281146 103/172 (60%)
EXS 260..600 CDD:281164 177/353 (50%)
XPR1NP_004727.2 SPX_XPR1_like 2..165 CDD:269898 102/170 (60%)
Important for inositol polyphosphate binding. /evidence=ECO:0000250|UniProtKB:P43585 158..165 6/6 (100%)
EXS 268..617 CDD:367343 177/355 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 402 1.000 Domainoid score I732
eggNOG 1 0.900 - - E1_COG5409
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H134226
Inparanoid 1 1.050 749 1.000 Inparanoid score I579
Isobase 1 0.950 - 0.569298 Normalized mean entropy S1995
OMA 1 1.010 - - QHG54286
OrthoDB 1 1.010 - - D125160at33208
OrthoFinder 1 1.000 - - FOG0000547
OrthoInspector 1 1.000 - - otm41780
orthoMCL 1 0.900 - - OOG6_100965
Panther 1 1.100 - - O PTHR10783
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1440
SonicParanoid 1 1.000 - - X439
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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