DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10483 and Y39A1A.22

DIOPT Version :9

Sequence 1:	NP_648000.1	Gene:	CG10483 / 38666	FlyBaseID:	FBgn0035649	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_499359.3	Gene:	Y39A1A.22 / 3565273	WormBaseID:	WBGene00012659	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	698	Identity:	313/698 - (44%)
Similarity:	427/698 - (61%)	Gaps:	51/698 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLTAHITPEWRKQYINYEEMKAMLYAAIEQSPSAELVEREMVTRYFAKFDEEFFHYCDKE 65
            |||.|.|.:|:|||||||||:||.:|.:||..:.:.|:.:....|.::|    .||:||:.||:|
Worm     1 MKFGEQLASHLTPEWRKQYIDYERLKNLLYDDMMEVPADDDRREEHISR----LDEKFFNECDQE 61

  Fly    66 LAKINTFYSEKMAEATRKYGSLRSELTEALE-MGHPKKLPAWKRRTPLGKKN----VPARKIQDL 125
            |.|||.|:|:|:||...|:..|::||....: :|........:||  .|.|:    ...|..|.|
Worm    62 LTKINLFFSQKIAEGQGKHHELQTELQVFKDVLGSRSDTTGIRRR--FGGKDKFHKETTRNEQQL 124

  Fly   126 KLAFSEFYLGLILLQNYQNLNFTGFRKILKKHDKLLSVDYGARWRTDHVEAAHFYTNKDIDRLIQ 190
            |||||||||.|:|:||:|.||.|||||||||||||...:.|..||.:.||.:.|:.|::|:.||.
Worm   125 KLAFSEFYLSLVLVQNFQQLNATGFRKILKKHDKLTGNERGLDWRINKVEKSSFFLNREIETLIT 189

  Fly   191 ETEQAVTQDIEGGDRQRAMKRLRVPPLGEQQSPWTTFKVGLFSGAFVVLFITVV---IAAMFYGF 252
            ..|.:|..|:|.|:||..||||:||||.|:|.|.|||.:|||.||.::|.:.::   ||:.....
Worm   190 NVETSVINDLEAGNRQAGMKRLKVPPLSEKQKPLTTFSLGLFIGASIILLLAILLTWIASPARPQ 254

  Fly   253 GENWRAGMRMFRAPFLIIECLFLWGVNVYGWRSSGVNHVLIFELDPRNHLSEQNIMEVASVFGVI 317
            ...|.| :|:||.|.|:...:||.|||:.||.::|||||||||:|||||||.|.:|::||...::
Worm   255 EPKWVA-VRLFRGPLLLFLSIFLCGVNMAGWAAAGVNHVLIFEVDPRNHLSYQTLMQIASFMIML 318

  Fly   318 WACCVLSYIFCDPLGIPQYAAPLCLYTLMAAFLLN----PTKTFHHEARFWAIRILIRVIMAPFC 378
            |:..||:|::...|.||.:|.||.|..:....|||    |...||..:|||.::...:...:||.
Worm   319 WSFAVLAYLYAHMLHIPPFAPPLALMVVCLILLLNPIAKPDSVFHRNSRFWLLKHCYKCFTSPFH 383

  Fly   379 FVNFADFWLADQLNSMVPAFLDIPFLICFFGR-------------------SPTWHKA----GKA 420
            ||.|.||||.||:||:..||||..:.:||:..                   |..|...    ||
Worm   384 FVTFTDFWLGDQMNSLTTAFLDFQYFVCFYATEVDYSNGWIEVKGINSTTGSVPWGSVELSNGK- 447

  Fly   421 ASHCVEYVSLLHPIVAIMPAYFRFAQCIRRYRDTKESFPHLVNAAKYATSFFVVIFA--HKYHTT 483
             ..|..... |..:::|:||..||.||:|||||||...||||||.||:|:||||...  :||:..
Worm   448 -DQCASAAG-LRSLMSIIPAMIRFLQCLRRYRDTKRVHPHLVNAGKYSTTFFVVACGALNKYYEA 510

  Fly   484 TDTYPLSKENPWFYCWITAAIFSSCYAYTWDIKMDWGLFDSKA-GDNRFLREEIVYSSTWFYYFG 547
            ||.   :..:.:||.||.:.|.|..|.:.|||.|||||.|.:| .:.||||||::|.|.|:||..
Worm   511 TDP---NTTSIFFYIWILSYIMSFTYTFLWDIFMDWGLIDPRAPKEARFLREEMIYGSKWYYYMA 572

  Fly   548 IIEDLILRFSWTLSMSLIEAGYIEGDVMMTILSPLEVFRRFIWNYFRLENEHLNNVGKFRAVRDI 612
            |.:|.:||.:|.|::||.||..::.|.:.|:.:|.|||||||||||||||||:||.|:|||||||
Worm   573 IAQDFVLRLAWVLNVSLGEAWTLDSDFLTTVTAPFEVFRRFIWNYFRLENEHVNNCGQFRAVRDI 637

  Fly   613 SVAPMDCSDQTTILRMMDETDGVLNRRRGKAAGGKSATKKNKQEQRLL 660
            ||.|:...|..::|..||:.|||.:|.:......|...|..|..::||
Worm   638 SVKPIRKGDLESLLSKMDQMDGVTHRGQDLMERVKKQKKSAKASRQLL 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10483	NP_648000.1	SPX_XPR1_like	2..159	CDD:269898	76/161 (47%)
		SPX	3..162	CDD:281146	78/163 (48%)
		EXS	260..600	CDD:281164	165/369 (45%)
Y39A1A.22	NP_499359.3	SPX_XPR1_like	2..158	CDD:269898	76/161 (47%)
Y39A1A.22	NP_499359.3	EXS	262..625	CDD:308637	165/368 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I608
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I519
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm14193
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.820