DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10483 and xpr1a

DIOPT Version :9

Sequence 1:	NP_648000.1	Gene:	CG10483 / 38666	FlyBaseID:	FBgn0035649	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001232029.1	Gene:	xpr1a / 100170805	ZFINID:	ZDB-GENE-060503-362	Length:	692	Species:	Danio rerio

Alignment Length:	685	Identity:	368/685 - (53%)
Similarity:	475/685 - (69%)	Gaps:	24/685 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLTAHITPEWRKQYINYEEMKAMLYAAIEQSPSAELVEREMVTRYFAKFDEEFFHYCDKE 65
            |||||||:||||||||||||.||..|.|||||.:|:||.|:.:.:.|.||:|||:|:||..|:||
Zfish     1 MKFAEHLSAHITPEWRKQYIQYEAFKEMLYAAQDQAPSLEVTDEDTVKRYYAKFEEKFFQTCEKE 65

  Fly    66 LAKINTFYSEKMAEATRKYGSLRSELTEALEMGHPKKLPAWKRR----TPL-GKKNVPARKIQDL 125
            |:|||||||||:|||.|::.:|::||..:|:.......||.:.|    .|| .|:....|.|:||
Zfish    66 LSKINTFYSEKLAEAQRRFATLQNELQTSLDAQRESNAPALRSRRKTVLPLSNKERNKHRNIKDL 130

  Fly   126 KLAFSEFYLGLILLQNYQNLNFTGFRKILKKHDKLLSVDYGARWRTDHVEAAHFYTNKDIDRLIQ 190
            :||||||||.||||||||||||||||||||||||:|....||.||..|||.|.|||.|.|.:||.
Zfish   131 QLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILDTPRGADWRVAHVEVAPFYTCKKITQLIS 195

  Fly   191 ETEQAVTQDIEGGDRQRAMKRLRVPPLG-EQQSP-WTTFKVGLFSGAFVVLFITVVIAAMFYGFG 253
            |||..||.::||||||:||||||||||| .|.:| ||||:|||:.|.|:||.:..|:...|:...
Zfish   196 ETEALVTTELEGGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGVFIVLAVAFVLTGAFFVRK 260

  Fly   254 ENWRAGMRMFRAPFLIIECLFLWGVNVYGWRSSGVNHVLIFELDPRNHLSEQNIMEVASVFGVIW 318
            :|....:|::|..||:::.|||.|:|.||||.:||||||||||:|||:||.|::.|:|...||:|
Zfish   261 QNIWPLVRIYRGGFLLVQFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGVLW 325

  Fly   319 ACCVLSYIFCDPLGIPQYAAPLCLYTLMAAFLLNPTKTFHHEARFWAIRILIRVIMAPFCFVNFA 383
            ...:||.:|.|...:|..|.||.||..|..||:||.||.::::|||.|::|.||..|||..|.||
Zfish   326 CLSILSCLFADYTWLPMQANPLILYGFMLLFLINPFKTAYYKSRFWLIKLLFRVFTAPFHRVEFA 390

  Fly   384 DFWLADQLNSMVPAFLDIPFLICFFGRSPTWHK------AGKAASHCVEYVSLLHPIVAIMPAYF 442
            ||||||||||:|....|:.:|:|::.....|.:      |......|..:...:..|:..:||:.
Zfish   391 DFWLADQLNSLVIVLSDLEYLVCYYSMELQWGERNGLLPAKFGDERCNSFSYGVRAIIHCLPAWL 455

  Fly   443 RFAQCIRRYRDTKESFPHLVNAAKYATSFFVVIFAHKYHTTTDTYPLSKENPWFYCWITAAIFSS 507
            ||.||:||||||:.:|||||||.||:|:||||.||..|.|..|......| .:||..:.::|.||
Zfish   456 RFVQCLRRYRDTRRAFPHLVNAGKYSTTFFVVTFAALYRTHKDQNHADSE-VFFYMLVLSSIVSS 519

  Fly   508 CYAYTWDIKMDWGLFDSKAGDNRFLREEIVYSSTWFYYFGIIEDLILRFSWTLSMSLIEAGYIEG 572
            .|...||:||||||||..||:|.||||||||....:||..||||::|||:|||.:||.....|..
Zfish   520 LYTLIWDLKMDWGLFDRNAGENTFLREEIVYPHKAYYYCAIIEDVLLRFAWTLQISLTSMTRIPS 584

  Fly   573 --DVMMTILSPLEVFRRFIWNYFRLENEHLNNVGKFRAVRDISVAPMDCSDQTTILRMMDETDGV 635
              |:::|||:||||||||:||:||||||||||.|:|||||||||||::..|||.:.:|||:.|||
Zfish   585 IEDIVVTILAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQEDGV 649

  Fly   636 LNRRRGKAAGGKSATKK--NKQEQRLLLQGESIED 668
            .||:      ||.:.|:  :...:|.||..:|.:|
Zfish   650 RNRQ------GKKSWKRSYSLSLRRPLLSSQSKKD 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10483	NP_648000.1	SPX_XPR1_like	2..159	CDD:269898	100/161 (62%)
		SPX	3..162	CDD:281146	101/163 (62%)
		EXS	260..600	CDD:281164	176/347 (51%)
xpr1a	NP_001232029.1	SPX_XPR1_like	2..164	CDD:269898	100/161 (62%)
		SPX	3..169	CDD:281146	102/165 (62%)
		EXS	284..614	CDD:281164	169/330 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I719
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134226
Inparanoid	1	1.050	740	1.000	Inparanoid score	I577
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		mtm6598
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870