DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	530	Identity:	139/530 - (26%)
Similarity:	222/530 - (41%)	Gaps:	36/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKEL 159
            |.::|..:|..|.|| :.:.:..:|...:.....| |||...| |.::|..|....|...:
Human     3 FSEILDRVGSMGHFQFLHVAILGLPILNMANHNLL-QIFTAAT-PVHHCRPPHNASTGPWV---- 61

  Fly   160 SIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPT------IPCKKGYVFEQEGRAFESAT 218
             :|...:|...||         :.|...|    |.|||.      .||..|:|:..   ..:|..
Human    62 -LPMGPNGKPERC---------LRFVHPP----NASLPNDTQRAMEPCLDGWVYNS---TKDSIV 109

  Fly   219 MEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFF 283
            .|:..:|:.:|....||.||..|.::|||..|..:|..||...|..|..|........:.|..|.
Human   110 TEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP 174

  Fly   284 TFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRF 348
            .:.:.|||.|...........||.:|:|..:.|.:::. :|...|:....::|.:|.:...||..
Human   175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMST-ALGYCYTFGQFILPGLAYAIPQWRWL 238

  Fly   349 SSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFY 413
            ....|:|..:...|....|||.||||..|:..|||:||:.|...|.|:...|.|.|.|.......
Human   239 QLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQK 303

  Fly   414 KEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLD-SENIFLFFTIACATE 477
            :..|....:|...:|:...:.|....:.|.|.:....|  :..|..|.: ..|:::...|....:
Human   304 EISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAY--YSLAMGVEEFGVNLYILQIIFGGVD 366

  Fly   478 LPGNILVILTLDRAGRRWCSFFYTSLSG--VFSLLGASFQNRANMRMSALAGRFFSNICYNIGLQ 540
            :|...:.||:|...||.........|:|  :.:|.......:....:.|:.|:...:..::....
Human   367 VPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFL 431

  Fly   541 WAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETL 605
            :.:|:.|||:|..|:...:....|..::||.|....:.......|:.|...:.||..||||||||
Human   432 YTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETL 496

  Fly   606 NHELPETLSD 615
            |..||||:.|
Human   497 NQPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	134/517 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	94/373 (25%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	134/517 (26%)
		MFS	96..493	CDD:119392	100/402 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950