DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a21

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	564	Identity:	143/564 - (25%)
Similarity:	259/564 - (45%)	Gaps:	50/564 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLF----LFMIPFCFI-TAFVYLGQIFMCLTPPKYYCYVPELLHTPVE 154
            |:::....:|.:|.||..:|    |.:||..|. .:.|:||.      .|.::|.:||.|:....
Zfish     5 DYEEQTAFLGAWGPFQKTVFSLLCLSIIPNGFTGLSIVFLGD------TPAHHCRIPETLNLTAG 63

  Fly   155 LRKELSIPKEK---DGSYSRCRMYNTNYTKIHFAEN---PSAYINTS-LPTIPCKKGYVFEQEGR 212
            .| ..|:|:.:   |...|||.....:..| ::::.   |...:|.| :|...|..|:::::|
Zfish    64 WR-NASVPRPQPHGDPRASRCYRLRLDLVK-NYSDGGLLPGLDVNVSEIPREECADGWIYDKE-- 124

  Fly   213 AFESATMEFGW--LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLA 275
             ..|:|:...|  :|.||..:.....|||.|.:.|.:..|..:|..||...|..:..:..:.::.
Zfish   125 -IYSSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQTLFTVV 188

  Fly   276 TSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIAL 340
            ...|..:..|....|:||....:.:...::|.:|.:....|.:.:.|.:.||:|...|::|..|.
Zfish   189 QVFSPSWQIFCFLFFIVGMGQISNYVAAFVLGMEILSSSVRDVYSTLGVCLFFSIGYMILPLAAF 253

  Fly   341 SAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLF 405
            ...:||......::|....:..:..:|||.|||:|.|.:.:|..|::...::|:......|..|.
Zfish   254 FLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAIIRKAAKINRVTAPDVIFPLM 318

  Fly   406 EASCTQFYKEELDG-RDFTVLSIFKRKRMARYMI-LMILIWMSISLVYDGHVRAASVLDSENIFL 468
            :::      |:..| :.|:|..:.|...: |||. |:.||||::|:.|.......|.|.. ||:|
Zfish   319 QST------EDAGGVQSFSVCELLKSSNI-RYMTGLLCLIWMAVSIGYCALSLNTSSLHG-NIYL 375

  Fly   469 FFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF-QNRANMRMS-ALAGRFFS 531
            ...::...|:|..::..|.|..|.||.|.....:|.|:..||.... ::::::.:: .:.|:|..
Zfish   376 NCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLLLILLIPEDQSSVTLALVMLGKFGL 440

  Fly   532 NICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGL 596
            :..::|.....||:.|||:|...:........|..:.:|...||.....|...|::|.:.:..||
Zfish   441 SAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPYFNYLGSYHRSLPYILIGGINVLSGL 505

  Fly   597 LALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHP 640
            |:..|||:....||||:      |:.|.:       .|.:|..|
Zfish   506 LSFLLPESRGSALPETI------GQMQTV-------KGLKKHSP 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	135/525 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	92/374 (25%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	135/525 (26%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	92/372 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950