DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10486 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	541	Identity:	142/541 - (26%)
Similarity:	256/541 - (47%)	Gaps:	37/541 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FDDLLPMIGQFGRFQ-IRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPEL--LHTPVELRK 157
            |:|:|..||.|.:|| :.|::..:| ..|....:|...|:...|| ::|.:|.|  ..:.....|
Zfish     3 FEDVLREIGGFNKFQFLVLYILWLP-RVILPLHFLLHNFISGVPP-HHCALPRLDGRFSASGAEK 65

  Fly   158 E-------LSIPKEKDGSYSRCRMYNTNYTKIHFAENPS---AYINTSLPTIPCKKGYVFEQEGR 212
            |       |.||:..|||||.|:||.   ..:.|..|..   .|.|.|..::||:.|:|:::...
Zfish    66 EELAQIVALGIPRNSDGSYSSCKMYT---MPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDRSQF 127

  Fly   213 AFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATS 277
            ...:|| |:..:||:.|........||:|..:|.:.:|..:|..||...:..|...:.|..:..:
Zfish   128 TSTTAT-EWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSSAVFGIIEA 191

  Fly   278 MSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSA 342
            .|:.:..|||:|.|.|.:..........|.:|:...|:||....: ::|.:|...|::..:|...
Zfish   192 FSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTI-ISLGWSVGNMLLALLAYLI 255

  Fly   343 GNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEA 407
            .:||......:.|.::.:.::..:|||||||::.|.:::|.:.|.|..::|.|....:.||:  .
Zfish   256 RDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGKYSYTKKLDI--E 318

  Fly   408 SCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDG---HVRAASVLDSENIFLF 469
            :..:....|...::.:.|.:.:..::.:.::...:.|.:::..|.|   ::....:    ||:|.
Zfish   319 NLKKITIAEDSNKNHSYLDLVRTPKLRKIVLCSGIFWFAVAFTYYGISFNITGFGL----NIYLT 379

  Fly   470 FTIACATELPGNILVILTLDRAGRR----WCSFFYTSLSGVFSLLGASFQNRANMRMS-ALAGRF 529
            ..|....|:|..:...|||||.|||    |......:|.|:.|::...|   |.:|.. |:.|:.
Zfish   380 QFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAGALIGLNSVIPTEF---AAVRTGIAVIGKG 441

  Fly   530 FSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFG 594
            ||...:.|...:.:|:.|||:|..|:.:...:..:...::|.|:...........:|..|..:|.
Zfish   442 FSEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFEDIWHYGPPVVFSATAVFS 506

  Fly   595 GLLALFLPETLNHELPETLSD 615
            |.:...||||.|.:|||.:.|
Zfish   507 GCVVFLLPETTNVQLPENILD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	136/528 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	87/378 (23%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	135/527 (26%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	87/375 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860