DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and Slc22a16

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_081848.1	Gene:	Slc22a16 / 70840	MGIID:	1918090	Length:	649	Species:	Mus musculus

Alignment Length:	666	Identity:	168/666 - (25%)
Similarity:	272/666 - (40%)	Gaps:	104/666 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 IGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELL-----HTPVELRKE---- 158
            ||.||||||.|:|............||..:|:.:. |::.|..|.::     |.....|.|
Mouse    13 IGHFGRFQIVLYLICAYQSLSCGIHYLSSVFLSII-PEHACKPPGMVRKAVFHNVSAWRLEDILA 76

  Fly   159 LSIPKEKD-----------GSYSRC-RMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEG 211
            |..|:.||           ...:|| |.:..|.:  |.....|.|.:.|    ||..|||::| .
Mouse    77 LRSPEHKDHIMVELQDGEIWELTRCSRTWRENTS--HLGYEYSGYKHDS----PCFDGYVYDQ-S 134

  Fly   212 RAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLAT 276
            :...||...|..:||...||...|.:...|.:||.:.:.:.:|..||..||..:........:|:
Mouse   135 KWRNSAVRNFNLVCDQKWYARMIQPLIIFGVMLGSITFSYLSDRFGRRMALWCTSIGVFFFGIAS 199

  Fly   277 SMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALS 341
            ....|:.:|.|:||.:..:....|.:|::.|:|.:|.|.||. |::.|..|::...|::...:..
Mouse   200 LFIFDYLSFMITRFFLVMASSGYFVVVFVYVMEIIGKKARTW-ASIHLNTFFAIGAMLVALASYL 263

  Fly   342 AGNWRRFSSFTSLPIVLAMFSFC--LLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDL 404
            ...|..:...  |.||...|..|  :|||:..||:|.|...:|...:..:...||.. |.::::|
Mouse   264 LKTWWLYQII--LCIVTTPFILCCWMLPETPFWLLSEGRYKEAQGTVDTMAVWNKSS-SCDLVEL 325

  Fly   405 FEASCTQFY-KEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVL-DSENIF 467
            .....|:.: |.....|...:..:|....:|:..:::.|.|.:.:|.|  ::....|: ..||..
Mouse   326 LSLDVTRSHNKSPHSIRKHRLADLFHNLDVAKMTLIVWLDWFTANLGY--YMFGKEVIRRKENEP 388

  Fly   468 LFFTIACATELPGNILVILTLDRAGRRWCSFFY---TSLSGVFSLLGASFQNRANMRMSALAGRF 529
            |:..:..|.|:|..|.:.:.|.|.|||.....:   :||:.:..::..|....|...::.|....
Mouse   389 LYLLLVGAMEIPAYICLCIWLKRVGRRKTMLLFLLVSSLTCMLHVVMPSDYKTAKRMVALLVKSV 453

  Fly   530 FSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFG 594
            .|::...|.| :.||:.||.||...|...:.:..|:.:..|...:.||..:....|:.|.|.|..
Mouse   454 ISSVFAFIYL-YTAELYPTTVRCLAVGSSNMVSHVSSIFIPFTSHFSKVWIFLPQILFGILAILS 517

  Fly   595 GLLALFLP-----------ETLNHELPE---TLSDG-------------AQFGKNQRIWHMPCCG 632
            |||:|.||           ||...::||   :|.:|             ..|.:.   |.:....
Mouse   518 GLLSLKLPETQDTPMKSTWETTEQQVPENKDSLGEGPPDSFERWDSSRALSFAER---WGLSRAS 579

  Fly   633 P-----GSRKSHP-RHNW---------HQGSSLRTLSKDEFRSSKMYRKTKYRFESHPSPSSSDY 682
            |     ||.:..| ...|         .:|:|.|...:|               ||..|..:...
Mouse   580 PDAEKWGSGRVPPDAGKWGAGIAPPVTERGASGRASLED---------------ESGGSGRAPPE 629

  Fly   683 KGTE-EKEIRTYKYGN 697
            |.|| |.||...|..|
Mouse   630 KNTEMENEIENMKVSN 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	143/549 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	95/377 (25%)
Slc22a16	NP_081848.1	2A0119	14..535	CDD:273328	139/535 (26%)
		MFS	163..525	CDD:119392	93/368 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..560		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..649		20/82 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850