DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10486 and SLC22A5

DIOPT Version :9

Sequence 1:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens

Alignment Length:	570	Identity:	150/570 - (26%)
Similarity:	244/570 - (42%)	Gaps:	78/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DFDDLLPMIGQFGRFQIRLFLFMIPFCFI-TAFVYLGQIFMCLTPPKYYCYVPELL--------H 150
            |:|::...:|::|.|| ||..|::....| ..|..|..:|:..| |::.|.||:..        |
Human     3 DYDEVTAFLGEWGPFQ-RLIFFLLSASIIPNGFTGLSSVFLIAT-PEHRCRVPDAANLSSAWRNH 65

  Fly   151 T-PVELRKELSIPKEKDGSYSRCRMYN----TNYTKIHFAENPSAYINT-SLPTIPCKKGYVF-- 207
            | |:.||....:|..       ||.|.    .|::.:..  .|...::. .|....|..|:.|
Human    66 TVPLRLRDGREVPHS-------CRRYRLATIANFSALGL--EPGRDVDLGQLEQESCLDGWEFSQ 121

  Fly   208 ---------EQEGRAFESATMEFG----------W--LCDDDKYATYAQIIFFLGSILGGLAYGH 251
                     ||:..|:.:.....|          |  :|:||..|.....:||:|.:||....|.
Human   122 DVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQ 186

  Fly   252 FADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYR 316
            .:|..||...|..:..:....|.....|.:|..|.:...|||....:.:...::|..|.:|...|
Human   187 LSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR 251

  Fly   317 TLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDK 381
            .:.:.|.:.:||:...||:|..|....:||......::|.||.:..:..:|||.|||:|.|..::
Human   252 IIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEE 316

  Fly   382 ALEILKNVIEVNKKQVSKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMS 446
            |..|::...:.|...|...|.|..|.......|::    ...:|.:.:...:....|:.|::||:
Human   317 AEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQ----SHNILDLLRTWNIRMVTIMSIMLWMT 377

  Fly   447 ISLVYDGHVRAASVLDSEN----IFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVF 507
            ||:.|.|     ..||:.|    ||:...::...|:|..:|..|.|....||     |:..:.:|
Human   378 ISVGYFG-----LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRR-----YSMATALF 432

  Fly   508 SLLGAS---FQNRANMRMSALA------GRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGF 563
              ||.|   |.......:..||      |:|.....:::...:.||:.|||||..||....|...
Human   433 --LGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASR 495

  Fly   564 VAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLPETLNHELPETL 613
            :..::||..|||.........|::|:|.|...:|.|||||:....||:|:
Human   496 LGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	147/558 (26%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	103/383 (27%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	147/558 (26%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	105/387 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850